| Evidence that the renal response to volume expansion involves a blood-borne factor. | |
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MedLine Citation:
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PMID: 435585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of blood volume expansion in immature rats by blood from infants (J to J expansion) and mature animals (A to J) has been studied. A to J expansion results in an increased renal response to expansion which is greater than J to J, but not as great as when mature animals are expanded with blood from other matures (A to A) or pooled blood from infants (J to A). A to A and J to A expansions show no significant differences in renal responsiveness. The lack of an immature response is not due to differences in animal hydration since 2.5% volume expansion is on the flat part of dose response curve. Part of the scatter of the adult response is related to absolute levels of GFR which might indicate the existence of a filterable natriuretic factor or, alternatively, a dependence of renal responsiveness on filtered load. These results are interpreted to indicate that mature rats contain a natriuretic factor or an inhibitor of an antinatriuretic factor which is blood borne and is probably secreted in blood volume expanded rats. |
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Authors:
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S Solomon; S Hathaway; D Curb |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of the neonate Volume: 35 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1979 |
Date Detail:
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Created Date: 1979-07-16 Completed Date: 1979-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Blood Volume* Glomerular Filtration Rate Kidney / blood supply, physiology* Male Natriuresis* Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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