Document Detail


Evidence that the rat hippocampus has contrasting roles in object recognition memory and object recency memory.
MedLine Citation:
PMID:  23025831     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult rats with extensive, bilateral neurotoxic lesions of the hippocampus showed normal forgetting curves for object recognition memory, yet were impaired on closely related tests of object recency memory. The present findings point to specific mechanisms for temporal order information (recency) that are dependent on the hippocampus and do not involve object recognition memory. The object recognition tests measured rats exploring simultaneously presented objects, one novel and the other familiar. Task difficulty was varied by altering the retention delays after presentation of the familiar object, so creating a forgetting curve. Hippocampal lesions had no apparent effect, despite using an apparatus (bow-tie maze) where it was possible to give lists of objects that might be expected to increase stimulus interference. In contrast, the same hippocampal lesions impaired the normal preference for an older (less recent) familiar object over a more recent, familiar object. A correlation was found between the loss of septal hippocampal tissue and this impairment in recency memory. The dissociation in the present study between recognition memory (spared) and recency memory (impaired) was unusually compelling, because it was possible to test the same objects for both forms of memory within the same session and within the same apparatus. The object recency deficit is of additional interest as it provides an example of a nonspatial memory deficit following hippocampal damage.
Authors:
Mathieu M Albasser; Eman Amin; Tzu-Ching E Lin; Mihaela D Iordanova; John P Aggleton
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  126     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-14     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  659-69     Citation Subset:  IM    
Copyright Information:
PsycINFO Database Record (c) 2012 APA, all rights reserved.
Affiliation:
School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom. albasserm@lilly.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology
Exploratory Behavior / physiology
Hippocampus / physiology*
Male
Maze Learning / physiology*
Mental Recall / physiology*
Rats
Recognition (Psychology) / physiology*
Grant Support
ID/Acronym/Agency:
087855//Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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