Document Detail


Evidence that pregnancy specific glycoproteins regulate T-Cell function and inflammatory autoimmune disease during pregnancy.
MedLine Citation:
PMID:  15853745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The capacity of the pregnancy state to regulate T-cell function is well documented. A consequence of this regulation is that many T-cell mediated autoimmune disorders, including multiple sclerosis (MS) are suppressed during pregnancy. The suppression of MS during pregnancy is more potent than the currently available treatments for this disease. Thus, the study of immunoregulatory factors of pregnancy could potentially result in the discovery of novel MS treatments. The regulation of T-cell function during pregnancy is likely the result of significant hormonal changes and may well involve immunoregulatory proteins derived from the placenta. Pregnancy specific glycoproteins (PSGs) are the most abundant placentally derived glycoproteins in the maternal serum. The levels of PSGs are highest during the third trimester of pregnancy, a time marked by the most profound suppression of MS disease attacks. Recent studies by our laboratories, and others, suggest that PSGs regulate T-cell function. We propose this regulation occurs by two distinct, but complementary mechanisms. PSGs may regulate T-cell function by (1) directly signaling tetraspanins present on the cell surface and by (2) regulating T-cell function indirectly through signaling of tetraspanins expressed by macrophages and dendritic cells. In this report, we will review evidence implicating PSGs as important immunoregulatory proteins and discuss our recent findings regarding the mechanisms by which PSGs regulate T-cell function.
Authors:
Bruce F Bebo; Gabriela S Dveksler
Related Documents :
17108685 - Structure of the midterm placenta of the spotted hyena, crocuta crocuta, with emphasis ...
7944135 - Ish and pcr study with y-specific probe/primers.
25450205 - Autotaxin activity has a high accuracy to diagnose intrahepatic cholestasis of pregnancy.
7944125 - Prenatal determination of fetal rhesus d status by dna amplification of peripheral bloo...
24711815 - Ppar- γ regulates trophoblast differentiation in the bewo cell model.
8636265 - Clinical performances of galactosyl hydroxylysine, pyridinoline, and deoxypyridinoline ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current drug targets. Inflammation and allergy     Volume:  4     ISSN:  1568-010X     ISO Abbreviation:  Curr Drug Targets Inflamm Allergy     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2005-08-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101160019     Medline TA:  Curr Drug Targets Inflamm Allergy     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
Affiliation:
Neurological Sciences Institute, Oregon Health & Science University, Portland, OR, USA. bebob@ohsu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / physiopathology*
Encephalomyelitis, Autoimmune, Experimental / physiopathology
Female
Glycoproteins / physiology*
Humans
Multiple Sclerosis / physiopathology
Pregnancy
Pregnancy Complications / immunology*
Pregnancy Proteins / physiology*
Signal Transduction / physiology
T-Lymphocytes / physiology*
Grant Support
ID/Acronym/Agency:
AI51834/AI/NIAID NIH HHS; AT001517/AT/NCCAM NIH HHS; HD35832/HD/NICHD NIH HHS; NS47418/NS/NINDS NIH HHS; RG3165/RG/CSR NIH HHS; RG3435/RG/CSR NIH HHS
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Pregnancy Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  TCR peptide vaccination in multiple sclerosis: boosting a deficient natural regulatory network that ...
Next Document:  The role of CD8(+) T cells in multiple sclerosis and its animal models.