| Evidence that oocyte quality in younger women with diminished oocyte reserve is superior to those of women of advanced reproductive age. | |
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MedLine Citation:
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PMID: 19846257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence is provided supporting the hypothesis that the much improved prognosis for younger women with diminished oocyte reserve compared to women of advanced reproductive age is related to a difference in mechanism for oocyte depletion. For younger women the majority have had destruction of certain portions of their ovarian tissue but the remaining spared ovarian tissue has proportionately the same percentage of normal follicles as their age peers. The hypothesis continues that some factor that is responsible for earlier development of primary to antral follicles persists with the early conceptus and protects it from early programmed cell death. Thus by natural selection most women of advanced reproductive age have oocytes that fertilize normally and produce normal morphologic embryos, but lacking this apoptosis inhibiting factor dies very early between days 6 and 12 from fertilization. |
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Authors:
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J H Check; R Cohen |
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Publication Detail:
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Type: Journal Article Date: 2009-10-28 |
Journal Detail:
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Title: Medical hypotheses Volume: 74 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 264-7 Citation Subset: IM |
Affiliation:
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Camden, NJ, USA. laurie@ccivf.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Evidence-Based Medicine* Female Humans Infertility, Female / physiopathology* Models, Biological* Oocysts / cytology*, physiology* Pregnancy Pregnancy Outcome* |
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