Document Detail


Evidence that inhibition of erythropoiesis is important in the anemia of chronic renal failure.
MedLine Citation:
PMID:  7452088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have documented that serum from patients with chronic renal failure is capable of inhibiting erythropoiesis in vitro. Few data, however, link this finding with the pathophysiology of the anemia of uremia. To study this, we correlated hematocrits from uremic patients with the degree to which serum from these patients inhibited erythropoiesis, using two different in vitro systems. We studied patients receiving hemodialysis and patients with varying degrees of uremia not receiving dialysis and did serial studies on patients in whom long-term hemodialysis was initiated. Study of patients with varying degrees of renal failure showed that levels of inhibitor developed and increased as renal failure worsened and the hematocrit level fell. Finally, we found a fall in inhibitor level in those patients who had an increase in hematocrit after long-term hemodialysis. We interpret these data as evidence that inhibition of erythropoiesis is involved in the anemia of chronic renal failure.
Authors:
S F Wallner; R M Vautrin
Related Documents :
1563428 - Hemodialysis related venous stenoses: treatment with self-expanding endovascular prosth...
19733948 - Soluble cd14 levels, interleukin 6, and mortality among prevalent hemodialysis patients.
2032398 - Correction of hypophosphatemia in patients on hemodialysis using a calcium-free dialysa...
19030738 - Blastocystis sp. and other intestinal parasites in hemodialysis patients.
10133648 - Interhospital transfer of cardiac patients: does air transport make a difference?
17913758 - Is the degree of cognitive impairment in patients with alzheimer's disease related to t...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  97     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2011-02-23    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  170-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anemia / etiology*
Colony-Forming Units Assay
Erythropoiesis*
Hematocrit
Heme / biosynthesis
Humans
Kidney Failure, Chronic / complications,  physiopathology*
Chemical
Reg. No./Substance:
14875-96-8/Heme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Determination of normal human serum erythropoietin levels, using mouse bone marrow.
Next Document:  The nature of the prostaglandin-producing mononuclear cell in human peripheral blood.