Document Detail

Evidence that high serum progesterone (P) levels on day of human chorionic gonadotropin (hCG) injection have no adverse effect on the embryo itself as determined by pregnancy outcome following embryo transfer using donated eggs.
MedLine Citation:
PMID:  21077517     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine if too high of a level of progesterone at the time of peak follicular maturation of donors adversely affects pregnancy or implantation rates of recipients.
METHODS: A retrospective cohort analysis was performed on donor egg recipients. Pregnancy rates were calculated according to ranges of five serum progesterone (P) levels based on two standard deviations before and above the mean.
RESULTS: No adverse effect was found in recipients whose donors had serum P levels between 2.47 and 3.41 ng/ml. There may have been a slightly lower pregnancy rate in recipients whose donors had seen P levels over 3.41 but there were only seven patients in that group and there still was a live delivered pregnancy rate of 28.6% per transfer.
CONCLUSIONS: The main adverse effect of a premature rise of progesterone in women making multiple follicles with gonadotropin stimulation seems to be on the endometrium. There appear to be enough follicles not affected by the progesterone to recommend proceeding with oocyte retrieval in the donor so as not to waste money on expensive medication and monitoring.
J H Check; C Wilson; J K Choe; J Amui; D Brasile
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  37     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-16     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  179-80     Citation Subset:  IM    
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage
Cohort Studies
Embryo Transfer*
Follicular Phase
Oocyte Donation*
Pregnancy Outcome
Pregnancy Rate*
Progesterone / blood*
Reproductive Control Agents / administration & dosage
Retrospective Studies
Tissue Donors
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Reproductive Control Agents; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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