Document Detail


Evidence that heme d1 is a 1,3-porphyrindione.
MedLine Citation:
PMID:  3828288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heme d1 is the noncovalently associated heme prosthetic group of the bacterial nitrite reductase known as cytochrome cd1. Additional evidence has been obtained in support of a dioxoisobacteriochlorin, or 1,3-porphyrindione, skeleton for this heme. The new data include the natural abundance 13C NMR spectrum of the free base methyl ester derivative of d1, mass spectrometric determinations of the molecular mass of the free base methyl ester and the Cu and the Zn chelates, visible and 1H NMR spectral comparisons between d1 and synthetic porphyrindione model compounds, and the isolation and characterization of several byproducts formed during the purification of the free base methyl ester of d1. The accumulated evidence strongly supports the following structure for the skeleton of d1: 1-oxo-2-methyl-2'-acetyl-3-oxo-4-methyl-4'-acetyl-5-methyl-6-acrylyl+ ++-7- propionyl-8-methylporphyrin.
Authors:
C K Chang; R Timkovich; W Wu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemistry     Volume:  25     ISSN:  0006-2960     ISO Abbreviation:  Biochemistry     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8447-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bacteria / enzymology
Heme / analogs & derivatives*
Magnetic Resonance Spectroscopy
Molecular Conformation
Nitrite Reductases
Porphyrins*
Spectrophotometry
Grant Support
ID/Acronym/Agency:
GM36264/GM/NIGMS NIH HHS; GM36520/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Porphyrins; 14875-96-8/Heme; 59948-35-5/heme d1; EC 1.7.-/Nitrite Reductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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