Document Detail

Evidence that heme d1 is a 1,3-porphyrindione.
MedLine Citation:
PMID:  3828288     Owner:  NLM     Status:  MEDLINE    
Heme d1 is the noncovalently associated heme prosthetic group of the bacterial nitrite reductase known as cytochrome cd1. Additional evidence has been obtained in support of a dioxoisobacteriochlorin, or 1,3-porphyrindione, skeleton for this heme. The new data include the natural abundance 13C NMR spectrum of the free base methyl ester derivative of d1, mass spectrometric determinations of the molecular mass of the free base methyl ester and the Cu and the Zn chelates, visible and 1H NMR spectral comparisons between d1 and synthetic porphyrindione model compounds, and the isolation and characterization of several byproducts formed during the purification of the free base methyl ester of d1. The accumulated evidence strongly supports the following structure for the skeleton of d1: 1-oxo-2-methyl-2'-acetyl-3-oxo-4-methyl-4'-acetyl-5-methyl-6-acrylyl+ ++-7- propionyl-8-methylporphyrin.
C K Chang; R Timkovich; W Wu
Related Documents :
21701718 - Proton mobility and stability of water clusters containing the bisulfate anion, hso(4)(...
20203908 - Fourier transform infrared spectroscopic study of molecular interactions in hemoglobin.
21656638 - Packed to the rafters: filling up c(60) with rare gas atoms.
12501198 - Plastocyanin-cytochrome f interactions: the influence of hydrophobic patch mutations st...
21451858 - Imaging ch(3)sh photodissociation at 204 nm: the sh + ch(3) channel.
11600778 - Anti-inflammatory drugs. x. hydrated pyrrolidinium [2-[(2,6-dichlorophenyl)amino]phenyl...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemistry     Volume:  25     ISSN:  0006-2960     ISO Abbreviation:  Biochemistry     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8447-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bacteria / enzymology
Heme / analogs & derivatives*
Magnetic Resonance Spectroscopy
Molecular Conformation
Nitrite Reductases
Grant Support
Reg. No./Substance:
0/Porphyrins; 14875-96-8/Heme; 59948-35-5/heme d1; EC 1.7.-/Nitrite Reductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of the thermally driven B to Z transition by intercalating drugs.
Next Document:  ATP-induced dissociation of rabbit skeletal actomyosin subfragment 1. Characterization of an isomeri...