Document Detail


Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-beta signalling.
MedLine Citation:
PMID:  21525052     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastropods are characterized by their asymmetric bodyplan, which develops through a unique ontogenetic process called 'torsion'. Despite several intensive studies, the driving force of torsion remains to be determined. Although torsion was traditionally believed to be driven by contraction of the retractor muscle connecting the foot and the shell, some recent reports cast doubt on that idea. Here, we report that torsion is accompanied by left-right asymmetric cell proliferation in the mantle epithelium in the limpet Nipponacmea fuscoviridis. Furthermore, we found that pharmacological inhibition of the transforming growth factor-β (TGF-β) signalling pathway, including that of Nodal, blocked torsion. We confirmed that the blocking was brought about through failure of the activation of cell proliferation in the right-hand side of the mantle epithelium, while the retractor muscle apparently developed normally. These results suggest that limpet torsion is driven by left-right asymmetric cell proliferation in the mantle epithelium, induced by the TGF-β pathway.
Authors:
Yoshihisa Kurita; Hiroshi Wada
Publication Detail:
Type:  Journal Article     Date:  2011-04-27
Journal Detail:
Title:  Biology letters     Volume:  7     ISSN:  1744-957X     ISO Abbreviation:  Biol. Lett.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-13     Completed Date:  2011-12-22     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101247722     Medline TA:  Biol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  759-62     Citation Subset:  IM    
Affiliation:
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan. katachiya@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation*
Gastropoda / cytology*
Signal Transduction*
Transforming Growth Factor beta / metabolism*
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta
Comments/Corrections

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