Document Detail

Evidence that the expression of progesterone-induced blocking factor by maternal T-lymphocytes is positively correlated with conception.
MedLine Citation:
PMID:  9266004     Owner:  NLM     Status:  MEDLINE    
PROBLEM: To compare the expression by T-lymphocytes of an immunomodulatory protein known as progesterone-induced blocking factor (PIBF) in conception versus non-conception cycles even when there has been definite fertilization and embryo formation. METHOD: PIBF expression on T lymphocytes was measured using an immunohistochemical method with a PIBF-specific polyclonal antibody. These levels were determined in patients undergoing three types of therapy: non-in vitro fertilization (IVF), IVF-embryo transfer (ET), and frozen ET. Sera were drawn 12 days from ovulation in non-IVF cycles or 9 days after ET and were assayed for PIBF and beta human chorionic gondotropin. Comparison of the frequency of lymphocyte expression of PIBF in pregnant versus non-pregnant women were made. RESULTS: PIBF was detected in 29.5% of non-pregnant women and 52.5% of pregnant women. There were no differences in PIBF levels by therapy used in non-pregnant cases or in the pregnant group. CONCLUSION: These data are consistent with the hypothesis that maternal expression of PIBF in T-lymphocytes soon after trophoblast invasion may depend on successful implantation.
J H Check; M Arwitz; J Gross; J Szekeres-Bartho; C H Wu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  38     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-30     Completed Date:  1997-09-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  6-8     Citation Subset:  IM    
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, USA.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood
Embryo Implantation / physiology*
Fertilization / physiology*
Pregnancy Proteins / biosynthesis*
Suppressor Factors, Immunologic
T-Lymphocytes / metabolism*
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/PIBF1 protein, human; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic

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