| Evidence that enhancement of cholinergic tone increases basal plasma levels of calcitonin gene-related peptide in normal man. | |
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MedLine Citation:
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PMID: 8126154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the influence of the cholinergic system on the modulation of the circulating levels of calcitonin gene-related peptide (CGRP) under basal conditions in normal man, the effects of an acetylcholinesterase inhibitor, pyridostigmine bromide, and a muscarinic receptor blocker, pirenzepine, were studied in 16 normal subjects (8 females and 8 males). Pyridostigmine (120 mg, orally) induced a significant (P < 0.01) rise in basal plasma CGRP, while it reduced systolic and diastolic blood pressure. In all subjects, pirenzepine (0.6 mg/kg, i.v. bolus) was unable to modify the basal CGRP level. In conclusion, a pharmacologically induced enhancement of cholinergic tone resulted in an increase in CGRP, whereas muscarinic receptor blockade had no effect on CGRP levels or blood pressure. Therefore, the cholinergic system seems to be involved in the control of CGRP release in man, acting as a positive modulator. However, the available data do not indicate that there is a tonic cholinergic tone responsible for CGRP secretion under physiological conditions. |
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Authors:
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G Trasforini; A Margutti; L Vergnani; M R Ambrosio; A Valentini; R Rossi; F Portaluppi; E C Degli Uberti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 78 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-04-12 Completed Date: 1994-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 763-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Endocrinology, University of Ferrara, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcitonin Gene-Related Peptide / blood* Female Humans Male Osmolar Concentration Parasympathetic Nervous System / drug effects, physiology* Pirenzepine / pharmacology Pyridostigmine Bromide / pharmacology Reference Values |
| Chemical | |
Reg. No./Substance:
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101-26-8/Pyridostigmine Bromide; 28797-61-7/Pirenzepine; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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