| Evidence that dopaminergic sympathetic axons supply the medullary arterioles of human kidney. | |
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MedLine Citation:
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PMID: 2722569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of the kidney to excrete sodium appears to depend on release of dopamine from intrarenal sources. In the present study, we have used immunohistochemistry to examine the possibility that renal dopaminergic nerves constitute one of these sources. We found that the sympathetic axons supplying cortical structures in human kidney contain tyrosine hydroxylase-like immunoreactivity but lack DOPA decarboxylase-like immunoreactivity. By contrast, the vasa recta arterioles of the renal medulla are supplied by varicose tyrosine hydroxylase-positive nerve fibres, some of which also contain DOPA decarboxylase. As DOPA decarboxylase has been demonstrated in other situations to be a selective marker for dopaminergic terminal axons, our results suggest the innervation of renal medullary blood vessels in man by both noradrenergic and dopaminergic sympathetic nerves. |
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Authors:
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C Bell; P S Bhathal; R Mann; G B Ryan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Histochemistry Volume: 91 ISSN: 0301-5564 ISO Abbreviation: Histochemistry Publication Date: 1989 |
Date Detail:
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Created Date: 1989-07-10 Completed Date: 1989-07-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0411300 Medline TA: Histochemistry Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 361-4 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Melbourne Medical Centre, Parkville, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteries / metabolism* Arterioles / metabolism* Axons / metabolism* Dopamine / metabolism* Female Humans Immunohistochemistry Kidney / blood supply, innervation* Male Sympathetic Nervous System / metabolism* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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