| Evidence that desferrioxamine cannot enter cells by passive diffusion. | |
| | |
MedLine Citation:
|
PMID: 2018567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Accumulation of [14C]desferrioxamine by rat visceral yolk sac in vitro has been compared with that of [14C]sucrose, a probe for fluid-phase pinocytosis. Kinetic parameters for both substrates are closely similar, as are the effects of inhibitors. It is concluded from these data, and from theoretical considerations, that desferrioxamine cannot enter cells other than by pinocytosis and that, once internalized, it will remain in the lysosomes. The results indicate the need for a re-evaluation of the pharmacokinetic mechanisms traditionally accepted for the drug's ability to deplete iron from cells and tissues. |
| | |
Authors:
|
J B Lloyd; H Cable; C Rice-Evans |
Related Documents
:
|
8064657 - Microcytosis and iron status in dogs with surgically induced portosystemic shunts. 16752077 - Lhrh-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metast... 5423947 - Studies on iron metabolism in sickle cell anaemia, sickle cell haemoglobin c disease, a... 15792797 - Regulation of divalent metal transporter expression in human intestinal epithelial cell... 7028727 - Bilinear cell growth of escherichia coli. 16270277 - 4-hydroxynonenal and cholesterol oxidation products in atherosclerosis. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Biochemical pharmacology Volume: 41 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1991 May |
Date Detail:
|
Created Date: 1991-05-17 Completed Date: 1991-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1361-3 Citation Subset: IM |
Affiliation:
|
Department of Biological Sciences, Keele University, Staffordshire, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Culture Techniques Deferoxamine / metabolism* Diffusion Pinocytosis* Rats Sucrose / metabolism Yolk Sac |
| Chemical | |
Reg. No./Substance:
|
57-50-1/Sucrose; 70-51-9/Deferoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polyene antibiotics increase the ionic permeability of synaptosomal plasma membranes.
Next Document: Inhibition of human leukocyte 5-lipoxygenase by a 4-hydroxybenzofuran, L-656,224. Evidence for enzym...