Document Detail

Evidence that desferrioxamine cannot enter cells by passive diffusion.
MedLine Citation:
PMID:  2018567     Owner:  NLM     Status:  MEDLINE    
Accumulation of [14C]desferrioxamine by rat visceral yolk sac in vitro has been compared with that of [14C]sucrose, a probe for fluid-phase pinocytosis. Kinetic parameters for both substrates are closely similar, as are the effects of inhibitors. It is concluded from these data, and from theoretical considerations, that desferrioxamine cannot enter cells other than by pinocytosis and that, once internalized, it will remain in the lysosomes. The results indicate the need for a re-evaluation of the pharmacokinetic mechanisms traditionally accepted for the drug's ability to deplete iron from cells and tissues.
J B Lloyd; H Cable; C Rice-Evans
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  41     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-17     Completed Date:  1991-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1361-3     Citation Subset:  IM    
Department of Biological Sciences, Keele University, Staffordshire, U.K.
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MeSH Terms
Culture Techniques
Deferoxamine / metabolism*
Sucrose / metabolism
Yolk Sac
Reg. No./Substance:
57-50-1/Sucrose; 70-51-9/Deferoxamine

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