Document Detail


Evidence that desferrioxamine cannot enter cells by passive diffusion.
MedLine Citation:
PMID:  2018567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accumulation of [14C]desferrioxamine by rat visceral yolk sac in vitro has been compared with that of [14C]sucrose, a probe for fluid-phase pinocytosis. Kinetic parameters for both substrates are closely similar, as are the effects of inhibitors. It is concluded from these data, and from theoretical considerations, that desferrioxamine cannot enter cells other than by pinocytosis and that, once internalized, it will remain in the lysosomes. The results indicate the need for a re-evaluation of the pharmacokinetic mechanisms traditionally accepted for the drug's ability to deplete iron from cells and tissues.
Authors:
J B Lloyd; H Cable; C Rice-Evans
Related Documents :
8064657 - Microcytosis and iron status in dogs with surgically induced portosystemic shunts.
16752077 - Lhrh-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metast...
5423947 - Studies on iron metabolism in sickle cell anaemia, sickle cell haemoglobin c disease, a...
15792797 - Regulation of divalent metal transporter expression in human intestinal epithelial cell...
7028727 - Bilinear cell growth of escherichia coli.
16270277 - 4-hydroxynonenal and cholesterol oxidation products in atherosclerosis.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  41     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-17     Completed Date:  1991-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1361-3     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Keele University, Staffordshire, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Culture Techniques
Deferoxamine / metabolism*
Diffusion
Pinocytosis*
Rats
Sucrose / metabolism
Yolk Sac
Chemical
Reg. No./Substance:
57-50-1/Sucrose; 70-51-9/Deferoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Polyene antibiotics increase the ionic permeability of synaptosomal plasma membranes.
Next Document:  Inhibition of human leukocyte 5-lipoxygenase by a 4-hydroxybenzofuran, L-656,224. Evidence for enzym...