Document Detail


Evidence that the decrease in liver glycogen is associated with the exercise-induced increase in IGFBP-1.
MedLine Citation:
PMID:  12133895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present study was to test the hypothesis that the exercise-induced increase in insulin-like growth factor binding protein (IGFBP)-1 is not always linked to a decrease in blood glucose level and to examine whether the decreasing levels of liver glycogen during exercise may be associated with the increase in IGFBP-1. Three groups of rats were submitted to a 70-min treadmill exercise. One group of rats was fed normally, and the two other groups had their food intake restricted by 50% (50% fast) the night before the experiment. One of these two 50% fasted groups of rats was infused (intravenously) with glucose throughout exercise to maintain euglycemia. Exercise in noninfused 50% fasted rats, compared with the normally fed rats, resulted in significantly lower blood glucose (minute 70) and insulin levels, significantly lower liver glycogen content, no change in IGF-I, and significantly higher increases in free fatty acid, glycerol, beta-hydroxybutyrate, and IGFBP-1. Maintenance of euglycemia during exercise in glucose-infused 50% fasted rats reduced to a large extent the decrease in insulin levels but only slightly attenuated the lipid response and the IGFBP-1 response seen in noninfused 50% fasted rats. Comparisons of all individual liver glycogen and IGFBP-1 values revealed that liver glycogen values were highly (P < 0.001) predictive of the IGFBP-1 response during exercise (R = 0.564). The present results indicate that the IGFBP-1 response during exercise is not always linked to a decrease in plasma glucose and suggest that the increase in IGFBP-1 during exercise may be related to the decrease in liver glycogen content.
Authors:
Jean-Marc Lavoie; Yovan Fillion; Karine Couturier; Pierre Corriveau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  93     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-22     Completed Date:  2003-02-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  798-804; discussion 797     Citation Subset:  IM    
Affiliation:
Département de Kinésiologie, Université de Montréal, Montréal, Québec, Canada H3C 3J7. jean-marc.lavoie@umontreal.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Caloric Restriction
Glycogen / metabolism*
Insulin / physiology
Insulin-Like Growth Factor Binding Protein 1 / metabolism*
Insulin-Like Growth Factor I / metabolism
Liver / metabolism*
Male
Muscle, Skeletal / physiology
Physical Exertion / physiology*
Rats
Rats, Sprague-Dawley
Signal Transduction / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; 0/Insulin-Like Growth Factor Binding Protein 1; 67763-96-6/Insulin-Like Growth Factor I; 9005-79-2/Glycogen

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