Document Detail


Evidence that abnormal myoelectrical activity produces colonic motor dysfunction in the irritable bowel syndrome.
MedLine Citation:
PMID:  832784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the irritable bowel syndrome is characterized as an abnormality in colonic motor activity occurring in response to certain stimuli, the etiology of this disorder is unclear. The purpose of this study is to determine the relationship of altered slow wave activity and the abnormal motility of the distal colon seen in patients with the irritable bowel syndrome. Myoelectrical activity was recorded using a bipolar electrode clipped to the distal colonic mucosa and motor activity was measured by perfused catheters. Colonic slow waves and contractions were present at two frequencies, 6 and 3 cycles per min. The slow wave frequency seemed to determine the frequency of colonic motor activity. Patients with the irritable bowel syndrome had increased 3-cycle per min slow wave activity in the basal state (P less than 0.001). However, no difference in basal 3-cycle per min motor activity was present between the two groups (P greater than 0.05). When colonic motor activity was increased with cholecystokinin or pentagastrin, patients with irritable bowel syndrome showed a marked increase in 3-cycle per min contractile activity, occurring simultaneously with 3-cycle per min slow wave activity. These studies suggest that increased colonic 3-cycle per min slow wave activity in patients with the irritable bowel syndrome may be the basic abnormality that leads to colonic motor dysfunction in response to various physiological stimuli.
Authors:
W J Snape; G M Carlson; S A Matarazzo; S Cohen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  72     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cholecystokinin / pharmacology
Colonic Diseases, Functional / etiology,  physiopathology*
Electrophysiology
Female
Gastrointestinal Motility
Humans
Male
Middle Aged
Motor Activity / physiology
Muscle, Smooth / physiopathology*
Pentagastrin / pharmacology
Chemical
Reg. No./Substance:
5534-95-2/Pentagastrin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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