Document Detail

Evidence that the (6-4) photolyase mechanism can proceed through an oxetane intermediate.
MedLine Citation:
PMID:  18763765     Owner:  NLM     Status:  MEDLINE    
Using the analogue of TpT methylated at the 3'-end N3 position (Tpm3T), we demonstrate that when the oxetane/(6-4) pathway is precluded, water addition occurs at the 3'-end C6 position of the oxetane intermediate to provide its opening. Photoreversal of this (6-4) photoproduct C6 hydrate brings the first experimental evidence that the (6-4) photolyase repair can proceed through an oxetane intermediate.
Saâdia Asgatay; Christian Petermann; Dominique Harakat; Dominique Guillaume; John-Stephen Taylor; Pascale Clivio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-03
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  130     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-19     Completed Date:  2008-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12618-9     Citation Subset:  IM    
Université de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims Cedex, France.
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MeSH Terms
DNA / chemistry,  metabolism
Deoxyribodipyrimidine Photo-Lyase / chemistry*,  metabolism
Ethers, Cyclic / chemistry*,  metabolism
Glycosides / chemistry,  metabolism
Imines / chemistry,  metabolism
Pyrimidine Dimers / chemistry*,  metabolism
Reg. No./Substance:
0/Ethers, Cyclic; 0/Glycosides; 0/Imines; 0/Pyrimidine Dimers; 0/pyrimidine-pyrimidone dimer; 503-30-0/oxetane; 9007-49-2/DNA; EC 4.1.99.-/pyrimidine(6-4)pyrimidone photolyase; EC Photo-Lyase

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