Document Detail

Evidence for a systemic defect of resistance-sized arterioles in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  8269185     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To investigate whether the abnormalities of coronary arterioles observed in association with hypertrophic cardiomyopathy represent a generalized phenomenon, both forearm and coronary vasodilator reserve were measured in 12 patients with hypertrophic cardiomyopathy. METHODS: Forearm vasodilator reserve was evaluated by measuring minimal forearm vascular resistance (Rmin, the ratio of mean intra-arterial pressure to peak forearm blood flow measured by venous plethysmography) under conditions of maximal postocclusive reactive hyperemia. RESULTS: In a subgroup (n = 5) of patients, the intra-arterial infusion of sodium nitroprusside combined with arterial occlusion did not produce additional vasodilation, indicating that the ischemic stimulus was indeed maximal. Coronary reserve was quantitated by measuring left ventricular blood flow (13N-ammonia and positron emission tomography) and coronary resistance at baseline and after intravenous dipyridamole (0.56 mg/kg). Rmin was significantly greater in patients than in a group of age- and sex-matched controls. The percentage change in coronary resistance after dipyridamole was significantly related to Rmin, whereas no correlation was found between change in coronary resistance and individual septal thickness values. CONCLUSIONS: Independent of cardiac hypertrophy, systemic and coronary arterioles of patients with hypertrophic cardiomyopathy are affected by an abnormality that may contribute to the clinical evolution of this syndrome.
R Pedrinelli; M Spessot; G Chiriatti; R Gistri; P Salvadori; G Catapano; G Panarace; L Papi; A L'Abbate; P G Camici
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  4     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1994-02-01     Completed Date:  1994-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
I Clinica Medica, University of Pisa, Italy.
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MeSH Terms
Cardiac Volume / drug effects,  physiology
Cardiomyopathy, Hypertrophic / physiopathology*,  ultrasonography
Coronary Circulation / drug effects,  physiology*
Dipyridamole / diagnostic use
Echocardiography / drug effects
Forearm / blood supply
Middle Aged
Muscle, Smooth, Vascular / drug effects,  physiopathology*
Nitroprusside / diagnostic use
Vascular Resistance / drug effects,  physiology*
Vasodilation / drug effects,  physiology
Reg. No./Substance:
15078-28-1/Nitroprusside; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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