Document Detail

Evidence for a suppression of apoptosis in early postnatal life.
MedLine Citation:
PMID:  11703194     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In fetal life the rates of proliferation and apoptosis are high. We studied if the rate of apoptosis decreases after birth, by measuring the soluble (s) forms of Fas-Fas ligand and Tumor necrosis factor receptor 1 (TNFR1)-TNF-alpha which attenuate apoptosis. SUBJECTS AND METHODS: Blood was drawn from the umbilical cord and from a peripheral vein on day 1 and 4 of life in 35 infants and sFas, sFas ligand, sTNFR1 and sTNF-alpha were determined by enzyme immunoassays. Data were analyzed by paired t-test and Pearson's correlation analysis. RESULTS: sFas and sTNF increased significantly from birth to day 4 of life (p=0.033 and p<0.0001 respectively), while sTNFR1 increased significantly from birth to day 1 of life (p<0.0001) followed by a significant decrease on day 4 of life (p<0.0001). The levels of sFas and sTNF-alpha on day 1 correlated with those on day 4 (r=0.677, p<0.0002 and r=0.525, p<0.007 respectively). sFAS ligand was not detectable in any specimen. CONCLUSION: The increasing concentrations of the soluble molecules, sFas, sTNF-alpha and sTNFR1 might indicate that apoptosis may be downregulated in early postnatal life.
A Malamitsi-Puchner; A Sarandakou; J Tziotis; P Trikka; G Creatsas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  80     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2001-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  994-7     Citation Subset:  IM    
Neonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, Soultani 19, Aretaieion Hospital, GR-10682 Athens, Greece.
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MeSH Terms
Antigens, CD95 / blood
Apoptosis / physiology*
Down-Regulation / physiology*
Fas Ligand Protein
Fetal Blood / chemistry
Infant, Newborn / blood,  physiology*
Membrane Glycoproteins / blood
Receptors, Tumor Necrosis Factor / blood
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Antigens, CD95; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha

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