| Evidence suggesting the importance of fatty acids and the fatty acid moieties of sperm membrane phospholipids in the acrosome reaction of guinea pig spermatozoa. | |
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MedLine Citation:
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PMID: 6423766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When guinea pig spermatozoa were preincubated 1 hr in Ca2+-free medium containing dilysocardiolipin (100--125 micrograms/ml) then exposed to Ca2+, the majority underwent an immediate acrosome reaction. Monolysocardiolipin was much less effective and the native cardiolipin was totally ineffective. Some fatty acids added to the medium could also render the spermatozoa capable of undergoing their acrosome reactions, arachidonic acid in methyl ester form being most potent. It is known that sperm membrane contains phospholipase A which cleaves membrane phospholipids into lysophospholipids and fatty acids. Most lysophospholipids are known to be potent acrosome reaction-promoting agents. As some forms of fatty acids are also potent acrosome reaction-promoting agents, both products of membrane phospholipid hydrolysis by phospholipase A (i.e., both fatty acids and lysophospholipids) may work synergistically to effect the conversion of stable sperm membranes to a fusion competent state capable of engaging in the acrosome reaction. |
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Authors:
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A D Fleming; R Yanagimachi |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of experimental zoology Volume: 229 ISSN: 0022-104X ISO Abbreviation: J. Exp. Zool. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-05-24 Completed Date: 1984-05-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375365 Medline TA: J Exp Zool Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 485-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrosome
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drug effects*,
physiology Animals Arachidonic Acid Arachidonic Acids / pharmacology Calcium / pharmacology Cardiolipins / pharmacology* Fatty Acids / pharmacology* Guinea Pigs Male Membrane Lipids / physiology* Polyvinyl Alcohol / pharmacology Serum Albumin, Bovine / pharmacology Spermatozoa / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HD-03402/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Cardiolipins; 0/Fatty Acids; 0/Membrane Lipids; 0/Serum Albumin, Bovine; 506-32-1/Arachidonic Acid; 7440-70-2/Calcium; 9002-89-5/Polyvinyl Alcohol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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