Document Detail

Evidence of subclinical intestinal inflammation by 99m technetium leukocyte scintigraphy in patients with HLA-B27 positive juvenile onset active spondyloarthropathy.
MedLine Citation:
PMID:  10852286     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The concept that gut inflammation is implicated in the pathogenesis of spondyloarthropathies (SpA) has long been considered. Subclinical intestinal inflammation has been reported in adult patients with SpA by histological examination of intestinal biopsies. We assessed the presence of gut inflammation by abdominal 99mTc-hexamethyl propylene amine oxime (99mTc-HMPAO) labeled leukocyte scintigraphy in a group of children and adolescents with HLA-B27 positive SpA without gastrointestinal (GI) symptoms, and correlated the scintigraphic results to disease activity. METHODS: Abdominal scintigraphy with 99mTc-HMPAO labeled leukocytes was performed in 27 HLA-B27 positive children and adolescents with SpA without GI symptoms. Patients were divided into 2 groups according to the presence of active or inactive joint disease: Group A, 17 patients with active disease, and Group B, 10 patients with inactive disease. Patients with positive abdominal scintigraphy underwent complete bowel investigation by means of small bowel barium follow-through, abdominal ultrasound scan, and ileocolonoscopy with mucosal biopsies. RESULTS: Thirteen of 27 patients (48%) had scintigraphy indicating the presence of bowel inflammation. All patients with abnormal scan had active joint disease, whereas no patient with inactive disease had a positive intestinal uptake of labeled leukocytes. Bowel investigation revealed the presence of aspecific mucosal inflammatory changes in the majority of patients with positive scintigraphy. CONCLUSION: The presence of intestinal leukocyte uptake only in patients with active joint disease, even if intestinal inflammatory changes were minimal and clinical gut manifestations were absent, supports the role of gut inflammation in the pathogenesis of joint disease in HLA-B27 positive patients with SpA.
P Lionetti; A Pupi; M Veltroni; C Fonda; M C Cavicchi; C Azzari; F Falcini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  27     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-10-11     Completed Date:  2000-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1538-41     Citation Subset:  IM    
Department of Pediatrics, University of Florence, Italy.
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MeSH Terms
Age of Onset
HLA-B27 Antigen / analysis*
Ileum / immunology,  radionuclide imaging
Inflammatory Bowel Diseases / radionuclide imaging*
Leukocytes / radionuclide imaging*
Predictive Value of Tests
Radiopharmaceuticals / diagnostic use
Rheumatic Diseases / radionuclide imaging*
Spinal Diseases / radionuclide imaging*
Technetium Tc 99m Exametazime / diagnostic use
Reg. No./Substance:
0/HLA-B27 Antigen; 0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

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