| Evidence for stretch-induced resistance increase of proximal coronary microcirculation. | |
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MedLine Citation:
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PMID: 11709438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the influence of stretch on regional hemodynamic parameters of the septal circulation. We used a similar experimental setup and mathematical model, as described previously (14). Five ventricular septa were isolated from anesthetized dogs, sutured to a biaxial stretching apparatus, and perfused with an oxygenated perfluorochemical emulsion at maximal vasodilation. Under unloaded and biaxially stretched conditions, flow and septal thickness (to index vascular volume) were measured continuously. Pressure was varied sinusoidally at 30, 50, and 70 mmHg with amplitude of 7.5 mmHg over frequencies ranging between 0.015 and 7 Hz. Admittance (flow/pressure) and capacitance (thickness/pressure) transfer functions were calculated and interpreted in terms of a two-compartmental model with volume-dependent resistances. Parameter estimation showed that the proximal resistance and compliance were unaffected, whereas the resistance of the proximal part of the microcirculation, including the small arterioles, increased with stretch. The effect of stretch on the distal resistance and capacitance, however, could not be determined unequivocally. |
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Authors:
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A J Cornelissen; J A Spaan; J Dankelman; C C Chan; F C Yin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 281 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-11-15 Completed Date: 2002-01-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H2687-96 Citation Subset: IM |
Affiliation:
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Man Machine Systems and Control Group, Faculty of Design, Engineering and Production, Department of Biomedical Engineering and Mechanics, Delft University of Technology, 2628 CD Delft, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / physiology* Dogs Heart Septum / physiology Microcirculation / physiology Models, Cardiovascular* Stress, Mechanical Vascular Resistance / physiology* Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-44399/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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