| Evidence of specialized leukocyte-vascular homing interactions at the maternal/fetal interface. | |
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MedLine Citation:
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PMID: 10229078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In normal pregnancy, the maternal immune system fails to reject the fetus or the placenta as an allogeneic graft. We hypothesize that specialized mechanisms of leukocyte recruitment might limit access of circulating maternal immune cells to the maternal/fetal interface. During the critical period of initial trophoblast invasion there is an elegantly orchestrated progression of leukocyte homing events in the decidua basalis, associated with highly regulated expression of vascular addressins and segregation of specialized leukocyte subsets into well-defined decidual microdomains. Neutrophils are limited to the region of necrosis associated with enzymatic digestion at the leading edge of the invading trophoblast, where an almost linear array of maternal blood vessels displays the neutrophil ligand E-selectin. Cells with the phenotype of monocytes but expressing alpha4beta7 integrin are localized in the blood vessels of the specialized "vascular zone", which display the unusual combination of P-selectin (partially associated with platelets) and the alpha4beta7 ligand mucosal vascular addressin-1 (MAdCAM-1). Granulated metrial gland cells (alpha4+beta7-, probably alpha4beta1+) constitute a well-defined cluster positioned in the central decidua basalis around venules prominently expressing the alpha4beta1 ligand VCAM-1 (but not MAdCAM-1). T and B lymphocytes are rare. Our results suggest that selective mechanisms for regulating leukocyte access, associated with microdomain specialization within the decidua basalis, may play a fundamental role in immune regulation during the invasive period of placental development. |
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Authors:
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A Kruse; M J Merchant; R Hallmann; E C Butcher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of immunology Volume: 29 ISSN: 0014-2980 ISO Abbreviation: Eur. J. Immunol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-05-13 Completed Date: 1999-05-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1116-26 Citation Subset: IM |
Affiliation:
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Department of Pathology and the Digestive Disease Center, Stanford University Medical School, USA. Kruse@immu.mu-luebeck.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion Molecules Decidua / physiology E-Selectin / analysis Female Fetus / immunology* Immunoglobulins / analysis Leukocytes / physiology* Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mucoproteins / analysis P-Selectin / analysis Pregnancy Pregnancy, Animal / immunology* Vascular Cell Adhesion Molecule-1 / analysis |
| Grant Support | |
ID/Acronym/Agency:
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AI37832/AI/NIAID NIH HHS; DK38707/DK/NIDDK NIH HHS; GM37734/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/E-Selectin; 0/Immunoglobulins; 0/Madcam1 protein, mouse; 0/Mucoproteins; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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