Document Detail

Evidence for somatic pairing of chromosome 7 and 10 homologs in a follicular lymphoma.
MedLine Citation:
PMID:  8697418     Owner:  NLM     Status:  MEDLINE    
Fluorescence in situ hybridization using centromeric probes for chromosomes 7 and 10 in a follicular lymphoma revealed only one signal in about 40% of interphases, whereas two copies of each chromosome were consistently seen in metaphases. In four out of 18 metaphases both copies of chromosome 7 were situated close to one another. In contrast, two signals for chromosome 1 were seen in 94% of interphases, consistent with observations on metaphases. The findings suggest chromosome-specific somatic pairing, the functional significance of which is at present unknown, and reinforce previous evidence suggesting that care should be taken in the interpretation of interphase signal numbers using centromeric probes in neoplastic as well as normal material.
N B Atkin; Z Jackson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  89     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-30     Completed Date:  1996-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-31     Citation Subset:  IM    
Department of Cancer Research, Mount Vernon Hospital, Northwood, United Kingdom.
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MeSH Terms
Chromosome Aberrations*
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 10*
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 7*
DNA Probes
In Situ Hybridization, Fluorescence
Lymphoma, Follicular / genetics*
Middle Aged
Reg. No./Substance:
0/DNA Probes

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