Document Detail


Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imaging.
MedLine Citation:
PMID:  17826183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While the majority of axonal organization is established by birth in mammalian brains, axonal wiring and pruning processes, as well as myelination, are known to extend to the postnatal periods, where environmental stimuli often play a major role. Normal axonal and myelin development of individual white matter tracts of human in this period is poorly understood and may have a major role in cognitive development of human. In this study, we applied diffusion tensor imaging and normalization-based population analyses to 44 preteen children and 30 adult images. We observed highly significant changes of fiber orientations at regions that correspond to the superior longitudinal fasciculus during the first 5 years. The result is attributed to slow axonal and/or myelin maturation of this tract, which is believed to be involved in language functions.
Authors:
Jiangyang Zhang; Alan Evans; Laurent Hermoye; Seung-Koo Lee; Setsu Wakana; Weihong Zhang; Pamela Donohue; Michael I Miller; Hao Huang; Xiaoqing Wang; Peter C M van Zijl; Susumu Mori
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-08-08
Journal Detail:
Title:  NeuroImage     Volume:  38     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2008-01-18     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging / physiology*
Animals
Axons / physiology*
Brain / anatomy & histology*,  growth & development*
Brain Mapping / methods*
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Grant Support
ID/Acronym/Agency:
P01 EB001955-11/EB/NIBIB NIH HHS; P01 EB001955-12/EB/NIBIB NIH HHS; P01 EB001955-13/EB/NIBIB NIH HHS; P01 EB001955-14/EB/NIBIB NIH HHS; P01 EB001955-15/EB/NIBIB NIH HHS; P01EB001955/EB/NIBIB NIH HHS; P41 EB015909/EB/NIBIB NIH HHS; P41 RR015241/RR/NCRR NIH HHS; P41 RR015241-040003/RR/NCRR NIH HHS; P41 RR015241-050003/RR/NCRR NIH HHS; P41 RR015241-060003/RR/NCRR NIH HHS; P41 RR015241-078615/RR/NCRR NIH HHS; P41 RR015241-086350/RR/NCRR NIH HHS; P41RR15241/RR/NCRR NIH HHS; R01 AG020012/AG/NIA NIH HHS; R01 AG020012-01/AG/NIA NIH HHS; R01 AG020012-02/AG/NIA NIH HHS; R01 AG020012-02S1/AG/NIA NIH HHS; R01 AG020012-03/AG/NIA NIH HHS; R01 AG020012-04/AG/NIA NIH HHS; R01 AG020012-05/AG/NIA NIH HHS; R01 AG020012-06A1/AG/NIA NIH HHS; R01 AG020012-07/AG/NIA NIH HHS; R01AG20012/AG/NIA NIH HHS
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