Document Detail

Evidence for simultaneous bidirectional fluid flux across synovial lining in knee joints of anaesthetized rabbits.
MedLine Citation:
PMID:  1632960     Owner:  NLM     Status:  MEDLINE    
A recent model predicted a local synovial circulation of extravascular fluid in which capillary filtrate entered a joint cavity and fluid simultaneously drained out of the cavity via intercellular pathways distant from capillaries. Here, solutions of albumin (10-250 g l-1) were infused continuously into the knee joint cavity in fifteen anaesthetized rabbits at 3-18 cmH2O pressure and steady-state net trans-synovial flow was recorded. The intra-articular fluid collected after 15-30 min was substantially diluted despite a sustained net efflux from the cavity. This supports the prediction that net efflux comprises an influx of low-protein plasma ultrafiltrate and a larger efflux of joint fluid.
J N McDonald; J R Levick
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental physiology     Volume:  77     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-27     Completed Date:  1992-08-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  513-5     Citation Subset:  IM    
Department of Physiology, St George's Hospital Medical School, London.
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MeSH Terms
Albumins / pharmacokinetics
Biological Transport / physiology
Knee Joint / physiology*
Synovial Fluid / physiology*
Synovial Membrane / physiology*
Unconsciousness / physiopathology*
Reg. No./Substance:

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