Document Detail


Evidence of similar organization of the chromosomes carrying the major histocompatibility complex in man and other primates.
MedLine Citation:
PMID:  7002489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chromosome localization and gene synteny of the major histocompatibility complex (MHC) of the great apes and rhesus monkey were investigated using somatic cell hybrids. The presence of the MHC antigens was determined either with a microadsorption technique employing primate alloantisera, or with a radioimmune assay. The enzymes phosphoglucomutase 3 (PGM3), glyoxalase 1 (GLO1), mitochondrial superoxide dismutase (SOD2), and soluble maleic enzyme (ME1) were assayed in those hybrids where electrophoretic separations could be achieved. A chromosome homologous to the human No. 6 was found in the chimpanzee, gorilla, orangutan and rhesus monkey, and its genomic organization is similar to that of man.
Authors:
J J Garver; A M Estop; P Meera Khan; H Balner; P L Pearson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  27     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1980  
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  238-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosomes*
Chromosomes, Human, 6-12 and X
Cricetinae
Cricetulus
Fibroblasts
Genetic Markers
Gorilla gorilla / genetics
HLA Antigens / immunology
Hominidae / genetics
Humans
Hybrid Cells / analysis
Immunosorbent Techniques
Leukocytes
Macaca mulatta / genetics
Major Histocompatibility Complex*
Pan troglodytes / genetics
Species Specificity
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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