| Evidence for sequestration of polyglutamine inclusions by Drosophila myeloid leukemia factor. | |
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MedLine Citation:
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PMID: 15936212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracellular inclusions of abnormally long polyglutamine tracts and neurotoxicity are the hallmarks of several hereditary neurodegenerative disorders, including Huntington's disease (HD). In Drosophila melanogaster, dMLF, an ortholog of human myeloid leukemia factors, hMLF1 and hMLF2, suppressed polyglutamine toxicity and colocalized with the inclusions. In transfected primary rat neuronal cultures, dMLF and its orthologs reduced the morphological phenotypes and inclusions. Furthermore, dMLF reduced the recruitment of CBP and Hsp70 into the inclusions, both of which are among many essential proteins apparently trapped in the inclusions. These data suggest that a possible mechanism of suppression by dMLF is via the sequestration of polyglutamine oligomers or inclusions. |
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Authors:
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Woo-Yang Kim; Zahra Fayazi; Xiankun Bao; Dennis Higgins; Parsa Kazemi-Esfarjani |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 29 ISSN: 1044-7431 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-11 Completed Date: 2005-12-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 536-44 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Center for Neuroscience, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Down-Regulation / genetics Drosophila Proteins / genetics*, metabolism* Drosophila melanogaster Gene Expression Regulation / physiology HSP70 Heat-Shock Proteins / metabolism Humans Inclusion Bodies / genetics, metabolism*, pathology Neurodegenerative Diseases / genetics, metabolism*, physiopathology Neurons / metabolism*, pathology Nuclear Proteins / genetics, metabolism Peptides / metabolism* Proteins / genetics, metabolism Rats Repressor Proteins / genetics, metabolism Transfection |
| Grant Support | |
ID/Acronym/Agency:
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NS42162/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/HSP70 Heat-Shock Proteins; 0/MLF1 protein, human; 0/MLF2 protein, human; 0/Mlf protein, Drosophila; 0/Nuclear Proteins; 0/Peptides; 0/Proteins; 0/Repressor Proteins; 26700-71-0/polyglutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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