| Evidence of sequential opening and closing of lung units during inflation-deflation of excised rat lungs. | |
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MedLine Citation:
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PMID: 4059687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we propose a descriptive model of the events occurring in an excised lung during an inflation-deflation cycle. The model was developed by observing changes in small pressure-volume loops superimposed on quasistatic pressure volume curves. It was found that the shape of the small loops during lung inflation was a function of the previous end-expiratory pressure. These experimental results could most easily be explained by a model of the lung in which individual lung units open sequentially as the lung is inflated. During sequential recruitment, individual lung units open quickly to a volume determined by the transpulmonary pressure. The units then homogeneously increase and decrease in size according to pressure-volume curves similar to the deflation curve of the entire lung. Once lung units have been recruited, they remain open until the lung has been deflated to end-expiratory pressures below 3-4 cm H2O. Reducing the end-expiratory pressure to lower values causes additional derecruitment of lung units until a transpulmonary pressure of 0.0 to -1.0 cm H2O has been reached. |
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Authors:
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D G Frazer; K C Weber; G N Franz |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiration physiology Volume: 61 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-12-03 Completed Date: 1985-12-03 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 277-88 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Lung / physiology* Lung Compliance Lung Volume Measurements Pressure Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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