Document Detail

Evidence for a role of the plasma kallikrein-kinin system in acute inflammation: reduced exudation during carrageenin- and kaolin-pleurisies in kininogen-deficient rats.
MedLine Citation:
PMID:  3638906     Owner:  NLM     Status:  MEDLINE    
Experimental pleurisy was induced by intrapleural injection of carrageenin or kaolin in three strains of rat: Brown Norway-Katholiek (B/N-Ka), Brown Norway-Kitasato (B/N-Ki) and Sprague-Dawley (SD). B/N-Ka rats (kininogen-deficient) showed significantly less pleural fluid accumulation and exudation rate than SD rats or than B/N-Ki rats (normal). The result indicates the involvement of the plasma kallikrein-kinin system in these pleurisies and a role of high-molecular-weight kininogen is suggested.
S Oh-Ishi; I Hayashi; M Hayashi; K Yamaki; A Yamasu; T Nakano; I Utsunomiya; Y Nagashima
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  18     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-09-26     Completed Date:  1986-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  450-4     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Body Weight
Inflammation / enzymology,  physiopathology*
Kallikreins / metabolism*
Kininogens / metabolism*
Kinins / metabolism*
Organ Size
Pleurisy / enzymology,  physiopathology*
Rats, Inbred Strains
Species Specificity
Tetradecanoylphorbol Acetate
Reg. No./Substance:
0/Kininogens; 0/Kinins; 1332-58-7/Kaolin; 16561-29-8/Tetradecanoylphorbol Acetate; 9000-07-1/Carrageenan; EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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