Document Detail

Evidence for a role of neurotransmitters in the mechanism of topical convulsant models.
MedLine Citation:
PMID:  6145629     Owner:  NLM     Status:  MEDLINE    
In numerous studies on several species, alterations in putative neurotransmitters have been examined in a variety of topical models of epilepsy. The results of such studies provide evidence for alterations in the concentration of some neurotransmitters, alterations in the activity of synthetic and/or degradative enzymes, and alterations in uptake mechanisms and receptor density. The neurotransmitters for which the most consistent data are available include gamma-aminobutyric acid, acetylcholine, and glutamic and aspartic acids.
C R Craig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Federation proceedings     Volume:  43     ISSN:  0014-9446     ISO Abbreviation:  Fed. Proc.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-07     Completed Date:  1984-08-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372771     Medline TA:  Fed Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2525-8     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / physiology
Acetylcholinesterase / metabolism
Aspartic Acid / physiology
Brain / physiopathology
Choline O-Acetyltransferase / metabolism
Disease Models, Animal
Dopamine / physiology
Epilepsy / physiopathology*
Glutamates / physiology
Glutamic Acid
Neurotransmitter Agents / physiology*
Norepinephrine / physiology
Seizures / physiopathology*
Taurine / physiology
gamma-Aminobutyric Acid / physiology
Reg. No./Substance:
0/Glutamates; 0/Neurotransmitter Agents; 107-35-7/Taurine; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; EC O-Acetyltransferase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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