Document Detail

Evidence for a role of inhibition of sympathetic neurotransmission in the cardiovascular effects of intravenously administered verapamil.
MedLine Citation:
PMID:  8685077     Owner:  NLM     Status:  MEDLINE    
The effects of intravenous administration of verapamil, nifedipine and diltiazem on sympathetic stimulation-induced increase in heart rate (HR) and blood pressure (BP) have been investigated in chloralose-anaesthetized and artificially-ventilated cats. Verapamil (300 micrograms kg(-1) i.v.) produced a significant inhibition of sympathetically-induced tachycardia and pressor responses. The same dose of verapamil did not significantly alter adrenaline (2 micrograms kg(-1) i.v.) induced increase in HR and BP. In contrast, neither the sympathetically-induced nor the adrenaline-induced pressor and tachycardiac responses were significantly affected by nifedipine or diltiazem. These results demonstrate that peripherally administered verapamil but not nifedipine and diltiazem can inhibit cardiovascular sympathetic neurotransmission and this can possibly contribute to its effects on HR and BP.
S Gurtu; D Mukerjee; S Shukla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  31     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1996-08-20     Completed Date:  1996-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  383-6     Citation Subset:  IM    
Department of Pharmacology, King George's Medical College, Lucknow, India.
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MeSH Terms
Blood Pressure / drug effects*
Diltiazem / pharmacology
Epinephrine / pharmacology
Heart / drug effects,  innervation*
Heart Rate / drug effects
Injections, Intravenous
Nifedipine / pharmacology
Synaptic Transmission / drug effects*
Tachycardia / chemically induced*
Verapamil / pharmacology*
Reg. No./Substance:
21829-25-4/Nifedipine; 42399-41-7/Diltiazem; 51-43-4/Epinephrine; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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