Document Detail

Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease.
MedLine Citation:
PMID:  17729416     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the role of gastric mucosa at the secretion of sTREM-1 in peptic ulcer. METHODS: Seventy two patients were enrolled; 35 with duodenal, 21 with gastric ulcer and 16 with chronic gastritis. Patients were endoscoped and gastric juice was aspirated. Patients with duodenal and gastric ulcer underwent a second endoscopy post-treatment. Biopsies were incubated in the absence/presence of endotoxins or gastric juice. Supernatants were collected and sTREM-1 and TNFalpha were measured by enzyme immunoabsorbent assays. Scoring of gastritis was performed before and after treatment according to updated Sydney score. RESULTS: Patients with duodenal and gastric ulcer and those with chronic gastritis had similar scores of gastritis. sTREM-1 was higher in supernatants of tissue samples of H pylori-positive than of H pylori-negative patients with gastric ulcer. Median (+/- SE) sTREM-1 was found increased in supernatants of patients with gastric ulcer before treatment (203.21 +/- 88.91 pg/1000 cells) compared to supernatants either from the same patients post-treatment (8.23 +/- 5.79 pg/1000 cells) or from patients with chronic gastritis (6.21 +/- 0.71 pg/1000 cells) (P < 0.001 and < 0.001, respectively). Similar differences for sTREM-1 were recorded among LPS-stimulated tissue samples of patients (P = 0.001). Similar differences were not found for TNFalpha. Positive correlations were found between sTREM-1 of supernatants from patients with both duodenal and gastric ulcer before treatment and the degree of infiltration of neutrophils and monocytes. CONCLUSION: sTREM-1 secreted by the gastric mucosa is an independent mechanism connected to the pathogenesis of peptic ulcer. sTREM-1 was released at the presence of H pylori from the inflamed gastric mucosa in the field of gastric ulcer.
Vassilios Koussoulas; Spyridon Vassiliou; Ekaterini Spyridaki; Maria Demonakou; Ilia Vaki; Charalambos Barbatzas; Helen Giamarellou; Evangelos J Giamarellos-Bourboulis
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  13     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-30     Completed Date:  2007-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4610-4     Citation Subset:  IM    
Sismanoglion General Hospital, 1 Sismanogliou Str, Athens, Greece.
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MeSH Terms
Amoxicillin / administration & dosage
Anti-Bacterial Agents / therapeutic use
Anti-Ulcer Agents / administration & dosage
Chronic Disease
Clarithromycin / administration & dosage
Drug Administration Schedule
Duodenal Ulcer / drug therapy,  etiology,  metabolism*,  microbiology,  pathology
Endoscopy, Gastrointestinal
Gastric Juice / metabolism
Gastric Mucosa / drug effects,  microbiology,  pathology,  secretion*
Gastritis / complications,  drug therapy,  metabolism*,  microbiology,  pathology
Helicobacter Infections / complications,  drug therapy,  metabolism*,  microbiology,  pathology
Helicobacter pylori / isolation & purification
Lipopolysaccharides / pharmacology
Membrane Glycoproteins / secretion*
Middle Aged
Omeprazole / administration & dosage
Receptors, Immunologic
Severity of Illness Index
Stomach Ulcer / drug therapy,  etiology,  metabolism*,  microbiology,  pathology
Tissue Culture Techniques
Tumor Necrosis Factor-alpha / secretion
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Lipopolysaccharides; 0/Membrane Glycoproteins; 0/Receptors, Immunologic; 0/TREM1 protein, human; 0/Tumor Necrosis Factor-alpha; 26787-78-0/Amoxicillin; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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