| Evidence for a role of the cytoskeleton in the in vitro folliculogenesis of the thyroid gland of the fetal rat. | |
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MedLine Citation:
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PMID: 6091889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyrotropic hormone (TSH) or cAMP accelerate the formation of follicular cavities in the explanted thyroid gland of the 15-day-old rat fetus. Cytochalasin B or vinblastine and nocodazole or colchicine, which disorganize microfilamental and microtubular structures respectively, inhibit or completely block in vitro-induced folliculogenesis. Exposure of the thyroid tissue to lumicolchicine, a structural isomer of colchicine deprived of antimicrotubular activity, does not inhibit the activation of folliculogenesis induced by TSH. These results are strong evidence for the supposition that microfilaments and microtubules are involved in the TSH-stimulated mechanisms resulting in thyroid folliculogenesis. Folliculogenesis requires the integrity of both microfilaments and microtubules. |
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Authors:
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P Pic; L Remy; A M Athouel-Haon; E Mazzella |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell and tissue research Volume: 237 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-11-26 Completed Date: 1984-11-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 499-508 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclic AMP / pharmacology Cytochalasin B / pharmacology Cytoskeleton / ultrastructure* Dimethyl Sulfoxide / pharmacology Female Fetus Lumicolchicines / pharmacology Microscopy, Electron Organ Culture Techniques Pregnancy Rats Rats, Inbred Strains Thyroid Gland / drug effects, embryology*, ultrastructure* Thyrotropin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Lumicolchicines; 14930-96-2/Cytochalasin B; 490-24-4/lumicolchicine; 60-92-4/Cyclic AMP; 67-68-5/Dimethyl Sulfoxide; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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