Document Detail


Evidence for the role of the P2 protein of human rhinovirus in its host range change.
MedLine Citation:
PMID:  2539529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human rhinovirus 39 (HRV39) is blocked in nonpermissive L cells at both adsorption and intracellular replication steps. We have selected a host range variant of HRV39 capable of bypassing the intracellular replication block and found it to have altered nonstructural P2 proteins. These alterations are similar to those reported earlier for host range variants of HRV2 (F. H. Yin and N. B. Lomax, J. Virol. 48:410-418, 1983). This observation suggests that the intracellular replication block for both HRV2 and HRV39 in mouse L cells is at the same step. We propose that the P2 protein is an essential viral component that cannot function in mouse L cells unless altered. This alteration occurs spontaneously in stocks of HRV39 during growth in permissive HeLa cells.
Authors:
N B Lomax; F H Yin
Related Documents :
6159539 - Interferon treatment inhibits glycosylation of a viral protein.
1370739 - Cell-to-cell spread of hiv-1 occurs within minutes and may not involve the participatio...
22865609 - An innovative stand-alone bioreactor for the highly reproducible transfer of cyclic mec...
19463729 - Murine norovirus-1 entry into permissive macrophages and dendritic cells is ph-independ...
21154769 - Involvement of vilip-1 (visinin-like protein) and opposite roles of cyclic amp and gmp ...
4366059 - Oncornavirus expression in human x mouse hybrid cells segregating mouse chromosomes.
14520569 - Extensibility of isolated cell walls in the giant tip-growing cells of the xanthophycea...
8367469 - Probing the function of drosophila melanogaster accessory glands by directed cell ablat...
3736019 - Epithelial-interstitial cell interactions in fetal rat lung development accelerated by ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  63     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2396-9     Citation Subset:  IM    
Affiliation:
Central Research and Development Department, E.I. du Pont de Nemours and Company, Wilmington, Delaware 19880-0328.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Capsid / physiology*
Hela Cells
Humans
L Cells (Cell Line)
Molecular Weight
Precipitin Tests
RNA, Viral / biosynthesis
Receptors, Virus / physiology
Rhinovirus / growth & development*
Viral Core Proteins / physiology*
Viral Nonstructural Proteins
Viral Proteins / analysis,  immunology
Virus Replication*
Chemical
Reg. No./Substance:
0/RNA, Viral; 0/Receptors, Virus; 0/Viral Core Proteins; 0/Viral Nonstructural Proteins; 0/Viral Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Investigation of varicella-zoster virus infection of lymphocytes by in situ hybridization.
Next Document:  Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci.