Document Detail

Evidence for the role of the P2 protein of human rhinovirus in its host range change.
MedLine Citation:
PMID:  2539529     Owner:  NLM     Status:  MEDLINE    
Human rhinovirus 39 (HRV39) is blocked in nonpermissive L cells at both adsorption and intracellular replication steps. We have selected a host range variant of HRV39 capable of bypassing the intracellular replication block and found it to have altered nonstructural P2 proteins. These alterations are similar to those reported earlier for host range variants of HRV2 (F. H. Yin and N. B. Lomax, J. Virol. 48:410-418, 1983). This observation suggests that the intracellular replication block for both HRV2 and HRV39 in mouse L cells is at the same step. We propose that the P2 protein is an essential viral component that cannot function in mouse L cells unless altered. This alteration occurs spontaneously in stocks of HRV39 during growth in permissive HeLa cells.
N B Lomax; F H Yin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  63     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2396-9     Citation Subset:  IM    
Central Research and Development Department, E.I. du Pont de Nemours and Company, Wilmington, Delaware 19880-0328.
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MeSH Terms
Capsid / physiology*
Hela Cells
L Cells (Cell Line)
Molecular Weight
Precipitin Tests
RNA, Viral / biosynthesis
Receptors, Virus / physiology
Rhinovirus / growth & development*
Viral Core Proteins / physiology*
Viral Nonstructural Proteins
Viral Proteins / analysis,  immunology
Virus Replication*
Reg. No./Substance:
0/RNA, Viral; 0/Receptors, Virus; 0/Viral Core Proteins; 0/Viral Nonstructural Proteins; 0/Viral Proteins

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