Document Detail

Evidence for "response to injury" hypothesis.
MedLine Citation:
PMID:  7154855     Owner:  NLM     Status:  MEDLINE    
Role of platelet-derived growth factor (PDGF) in myointimal thickening described in "response to injury" hypothesis was investigated with artery of rats in culture and with air-injured artery of rats. PDGF promoted cell growth in ring preparation of carotid artery in culture denuded with citrate. It did not promote any cell growth in preparations without denudation. Trapidil, a PDGF antagonist, inhibited the cell growth promoted by PDGF in the denuded arterial ring. Systemic injection of PDGF was performed for 8 days to rats with thrombocytopenia induced by injections of anti-platelet serum. This treatment caused myointimal thickening of carotid artery 10 days after denudation by means of air injury. Trapidil at oral intake levels of 1, 3 and 30 mg/kg/day inhibited this change observed in denuded site of artery. Trapidil at oral intake of 6 mg/kg/day also inhibited myointimal thickening observed 15 days after denudation of carotid artery by air injury in normotensive and spontaneous hypertensive rats both with normal platelet counts. These results evidenced the role of PDGF in myointimal thickening described in "response to injury" hypothesis and clinical use of trapidil may be a new approach to the treatment of atherosclerosis.
H Ohnishi; K Yamaguchi; S Shimada; M Sato; H Funatc; Y Katsuki; T Dabasaki; Y Suzuki; Y Saitoh; A Kumagai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  31     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-03-17     Completed Date:  1983-03-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2595-602     Citation Subset:  IM    
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MeSH Terms
Arteriosclerosis / drug therapy,  etiology
Blood Platelets / immunology
Carotid Arteries / cytology
Carotid Artery Injuries*
Cell Division / drug effects
Growth Substances / pharmacology*
Hypertension / physiopathology
Immune Sera / pharmacology
Muscle, Smooth, Vascular / cytology,  drug effects
Peptides / pharmacology*
Platelet Aggregation / drug effects
Platelet Count
Platelet-Derived Growth Factor
Pyrimidines / pharmacology*
Rats, Inbred Strains
Thrombocytopenia / physiopathology
Trapidil / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Growth Substances; 0/Immune Sera; 0/Peptides; 0/Platelet-Derived Growth Factor; 0/Pyrimidines; 15421-84-8/Trapidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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