Document Detail

Evidence for a probenecid-sensitive transport system of acid monoamine metabolites from the spinal subarachnoid space.
MedLine Citation:
PMID:  403555     Owner:  NLM     Status:  MEDLINE    
The location of probenecid-sensitive elimination mechanisms of monoamine metabolites from the cerebrospinal fluid of the cat was determined with ventriculo-cisternal or ventriculo-lumbar perfusion techniques. These techniques were described in detail. Levels of endogenous homovanillic acid and 5-hydroxyindoleacetic acid were assayed in the perfusate. Probenecid administration induced the most marked increase of the levels of the monoamine metabolites in the ventriculo-lumbar perfusates. It was concluded that probenecid blocked the transport of both metabolites from the spinal subarachnoid space.
F W Van der Poel; H M Van Praag; J Korf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  52     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
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MeSH Terms
Biogenic Amines / metabolism*
Biological Transport, Active / drug effects
Homovanillic Acid / cerebrospinal fluid,  metabolism
Hydroxyindoleacetic Acid / cerebrospinal fluid,  metabolism
Probenecid / pharmacology*
Spinal Cord / drug effects,  metabolism
Subarachnoid Space / drug effects,  metabolism*
Time Factors
Reg. No./Substance:
0/Biogenic Amines; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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