Document Detail

Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain.
MedLine Citation:
PMID:  7609625     Owner:  NLM     Status:  MEDLINE    
The beta 3-adrenergic receptor (AR) is widely distributed in peripheral tissues, but up to now it has not been detected in the central nervous system. By using the polymerase chain reaction (PCR) technique, we found the beta 3-AR mRNA to be present in all the regions of the human brain we investigated. The quantities found were very low compared to those of the beta 1-AR and beta 2-AR mRNAs, being hardly detectable in adult brain. In contrast, the brain of very young infants contained about 100 times more beta 3-AR mRNA than the adult brain, whereas the amounts of beta 1-AR and beta 2-AR transcripts were essentially the same. In addition, using PCR we have cloned a central beta 3-AR coding region from a human frontal cortex cDNA library and have found it to be identical to the corresponding peripheral sequence.
M Rodriguez; C Carillon; A Coquerel; G Le Fur; P Ferrara; D Caput; D Shire
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Molecular brain research     Volume:  29     ISSN:  0169-328X     ISO Abbreviation:  Brain Res. Mol. Brain Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-15     Completed Date:  1995-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908640     Medline TA:  Brain Res Mol Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  IM    
Sanofi Recherche, Labège, France.
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MeSH Terms
Aged, 80 and over
Aging / metabolism*
Base Sequence
Brain Chemistry / physiology*
Child, Preschool
Middle Aged
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Messenger / analysis*
Receptors, Adrenergic, beta / genetics*
Receptors, Adrenergic, beta-1 / genetics
Receptors, Adrenergic, beta-2 / genetics
Receptors, Adrenergic, beta-3
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Adrenergic, beta; 0/Receptors, Adrenergic, beta-1; 0/Receptors, Adrenergic, beta-2; 0/Receptors, Adrenergic, beta-3

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