Document Detail

Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models.
MedLine Citation:
PMID:  23016514     Owner:  NLM     Status:  Publisher    
Autoimmune bullous diseases (AIBDs) are characterized by blisters and erosions on the skin and/or mucous membranes, which are caused by autoantibodies directed to structural proteins of the epidermis and the epidermal basement membrane zone. This Viewpoint Essay discusses the contribution by autoreactive T cells to the pathogenesis of bullous pemphigoid, pemphigus and epidermolysis bullosa acquisita, with an emphasis on studies using active animal mouse models for these diseases. Previous studies have demonstrated that cytokines produced by autoreactive T cells, the interaction between antigen-specific T cells and B cells and the function of regulatory T cells are likely related to the pathogenesis of AIBDs. In interpreting the experimental results, the limitations of those animal models should be considered. Further understanding of the pathogenicity of autoreactive CD4(+) T cells may lead to disease-specific treatments.
Hideyuki Ujiie; Hiroshi Shimizu
Related Documents :
23443554 - Haematopoietic cells produce bdnf and regulate appetite upon migration to the hypothala...
24724084 - Expression of mesenchymal stem cells-related genes and plasticity of aspirated follicul...
23180014 - Properties of monocytes generated from haematopoietic cd34(+) stem cells from bone marr...
24499274 - Biology of cd1- and mr1-restricted t cells.
2957334 - Suppressor cell induction by the anticancer drug spirogermanium.
10754294 - The cc chemokine ck beta-11/mip-3 beta/elc/exodus 3 mediates tumor rejection of murine ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  Experimental dermatology     Volume:  -     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  HIDEN: Hierarchical decomposition of regulatory networks.
Next Document:  Test-Retest, Responsiveness, and Minimal Important Change of the Ability to Perform Physical Activit...