| Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models. | |
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MedLine Citation:
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PMID: 23016514 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Autoimmune bullous diseases (AIBDs) are characterized by blisters and erosions on the skin and/or mucous membranes, which are caused by autoantibodies directed to structural proteins of the epidermis and the epidermal basement membrane zone. This Viewpoint Essay discusses the contribution by autoreactive T cells to the pathogenesis of bullous pemphigoid, pemphigus and epidermolysis bullosa acquisita, with an emphasis on studies using active animal mouse models for these diseases. Previous studies have demonstrated that cytokines produced by autoreactive T cells, the interaction between antigen-specific T cells and B cells and the function of regulatory T cells are likely related to the pathogenesis of AIBDs. In interpreting the experimental results, the limitations of those animal models should be considered. Further understanding of the pathogenicity of autoreactive CD4(+) T cells may lead to disease-specific treatments. |
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Authors:
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Hideyuki Ujiie; Hiroshi Shimizu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-20 |
Journal Detail:
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Title: Experimental dermatology Volume: - ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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