| Evidence for the ''paradox'' association between hypertensive lower esophageal sphincter and gastroesophageal reflux disease. | |
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MedLine Citation:
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PMID: 18299672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are several studies suggesting the paradoxical simultaneous presence of hypertensive lower oesophageal sphincter and gastroesophageal reflux disease. We present a case of a 22-year-old male patient who was examined in our outpatient clinic with oesophageal food bolus impaction during a meal, severe chest pain and drooling. Manometry revealed a hypertensive lower esophageal sphincter pressure (resting pressure 35 mmHg) and pHmetry revealed a DeMeester score > 14.72 (43.27). Six months after therapy with lansoprazole, manometry revealed a normal lower oesophageal sphincter (resting pressure 14 mmHg) and the DeMeester score was < 14.72 (5.89). The patient is now asymptomatic. This report is the only published case which exhibits the normalization of lower oesophageal pressure 6 months after gastroesophageal reflux disease management with lansoprazole, thus proving and establishing the above ''paradox''. |
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Authors:
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G Kouklakis; J Moschos; D Paikos; G Tagarakis; E Rouska; A Mpoumponaris; N Lyrantzopoulos; E Molyvas; G Minopoulos |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Minerva gastroenterologica e dietologica Volume: 54 ISSN: 1121-421X ISO Abbreviation: Minerva Gastroenterol Dietol Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-26 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9109791 Medline TA: Minerva Gastroenterol Dietol Country: Italy |
Other Details:
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Languages: eng Pagination: 97-100 Citation Subset: IM |
Affiliation:
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Medical School, Democritus University of Thrace Alexandroupolis, Greece. gtagarakis@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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therapeutic use Adult Angina Pectoris / etiology Deglutition Disorders / etiology Esophageal Sphincter, Lower / physiopathology* Gastroesophageal Reflux / complications*, drug therapy, physiopathology* Humans Male Manometry Pressure |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 103577-45-3/lansoprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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