Document Detail

Evidence of osteomalacia in an outpatient group of adult epileptics.
MedLine Citation:
PMID:  870316     Owner:  NLM     Status:  MEDLINE    
A review of 50 adult epileptics who had taken anticonvulsant drugs for 10 or more years showed a decrease in the concentration of serum phosphate and calcium and an increase in the activity of alkaline phosphatase in 22% of the patients. Plasma albumin and gamma-globulin levels were higher than in control subjects. All the patients lived at home and the dietary intake of calcium and vitamin D was often borderline normal or low. Six patients were submitted to bone biopsy and of these, 4 showed histological osteomalacia. Gastrointestinal disease did not appear to be a significant factor. None of the patients had symptoms or signs attributable to osteomalacia which does not seem to be of serious significance. All the patients were taking at least two drugs and it was not possible to assess the relative importance of the various drugs. A prospective study is needed. Measurements of serum calcium, phosphorus, and alkaline phosphatase should be performed at intervals on patients who are receiving anticonvulsant therapy. Treatment with calciferol may be indicated.
B Ashworth; D B Horn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  18     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
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MeSH Terms
Epilepsy / blood,  complications*,  drug therapy
Middle Aged
Osteomalacia / complications*
Phenobarbital / adverse effects
Phenytoin / adverse effects
Primidone / adverse effects
Time Factors
Reg. No./Substance:
125-33-7/Primidone; 50-06-6/Phenobarbital; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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