| Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells. | |
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MedLine Citation:
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PMID: 21440525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to its critical role in normal cell function, growth, and metabolism, zinc is implicated as a major factor in the development and progression of many pathological conditions and diseases. Despite this importance of zinc, many important factors, processes, and mechanisms of the physiology, biochemistry, and molecular biology of zinc remain unknown. Especially important is the unresolved issue regarding the mechanism and process of the trafficking, transport, and reactivity of zinc in cells; especially in mammalian cells. This presentation focuses on the concept that, due to the existence of a negligible pool of free Zn(2+) ions in the mammalian cell environment, the trafficking, transport and reactivity of zinc occurs via a direct exchange of zinc from donor Zn-ligands to acceptor ligands. This Zn exchange process occurs without the requirement for production of free Zn(2+) ions. The direct evidence from mammalian cell studies is presented in support of the operation of the direct Zn-ligand exchange mechanism. The paper also provides important information and conditions that should be considered and employed in the conduct of studies regarding the role and effects of zinc in biological/biomedical research; and in its clinical interpretation and application. |
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Authors:
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Leslie C Costello; Catherine C Fenselau; Renty B Franklin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-03-29 |
Journal Detail:
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Title: Journal of inorganic biochemistry Volume: 105 ISSN: 1873-3344 ISO Abbreviation: J. Inorg. Biochem. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-25 Completed Date: 2011-08-26 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 7905788 Medline TA: J Inorg Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 589-99 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA. lcostello@umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Cell Membrane / metabolism Cytosol / metabolism Humans Kinetics Ligands Mammals / metabolism Mitochondria / metabolism Models, Biological Zinc / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA071207-08/CA/NCI NIH HHS; R01 CA079903-09/CA/NCI NIH HHS; R01 DK042839-12/DK/NIDDK NIH HHS; R01CA79903/CA/NCI NIH HHS; R01DK42839/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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