Document Detail

Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia.
MedLine Citation:
PMID:  19631680     Owner:  NLM     Status:  MEDLINE    
Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.
A Caillaud; P de la Iglesia; M Camp?s; L Elandaloussi; M Fern?ndez; N Mohammad-Noor; K Andree; J Diog?ne
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-23
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  55     ISSN:  1879-3150     ISO Abbreviation:  Toxicon     Publication Date:    2010 Feb-Mar
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  633-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
IRTA, Ctra. Poble Nou, km. 5.5, 43540 Sant Carles de la R?pita, Spain.
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MeSH Terms
Biological Assay
Cell Line, Tumor
Chromatography, High Pressure Liquid
DNA / chemistry,  genetics
Dinoflagellida / chemistry,  metabolism*,  ultrastructure
Mass Spectrometry
Microscopy, Electron, Scanning
Okadaic Acid / chemistry,  metabolism*,  toxicity
Phosphoprotein Phosphatases / antagonists & inhibitors
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
78111-17-8/Okadaic Acid; 9007-49-2/DNA; EC Phosphatases

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