| Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia. | |
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MedLine Citation:
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PMID: 19631680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed. |
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Authors:
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A Caillaud; P de la Iglesia; M Camp?s; L Elandaloussi; M Fern?ndez; N Mohammad-Noor; K Andree; J Diog?ne |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-23 |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 55 ISSN: 1879-3150 ISO Abbreviation: Toxicon Publication Date: 2010 Feb-Mar |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: England |
Other Details:
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Languages: eng Pagination: 633-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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IRTA, Ctra. Poble Nou, km. 5.5, 43540 Sant Carles de la R?pita, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Assay Cell Line, Tumor Chromatography, High Pressure Liquid DNA / chemistry, genetics Dinoflagellida / chemistry, metabolism*, ultrastructure Malaysia Mass Spectrometry Mice Microscopy, Electron, Scanning Okadaic Acid / chemistry, metabolism*, toxicity Phosphoprotein Phosphatases / antagonists & inhibitors Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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78111-17-8/Okadaic Acid; 9007-49-2/DNA; EC 3.1.3.16/Phosphoprotein Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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