Document Detail


Evidence for a novel type of iron cluster in the respiratory chain of the archaeon Sulfolobus metallicus.
MedLine Citation:
PMID:  9720904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new type of metal centre was detected in the membranes of the thermoacidophilic archaeon Sulfolobus metallicus. This centre has an S = 1/2 ground state in the oxidised form, yielding an axial EPR signal with g values at 2.035 (g(parallel)) and 1.97 (g(perpendicular)), optimally detected at 4.6-10 K; in the reduced form it is EPR silent (even spin). These magnetic properties point to a spin-coupled iron cluster, with a minimum of two iron ions. The centre has a high reduction potential of +350 mV, at pH 6.5. The physiological role of this novel centre was probed through a general characterisation of S. metallicus respiratory chain: this archaeon contains NADH and succinate dehydrogenase activities, and cytochromes b562, a586 and a600 on the oxygen reductase system. Since it is reduced in the presence of succinate, and taking into account its high reduction potential, this centre is proposed to be a functional analogue of the Rieske centres.
Authors:
C M Gomes; H Huber; K O Stetter; M Teixeira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  432     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-18     Completed Date:  1998-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
Affiliation:
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / chemistry,  metabolism
Electron Spin Resonance Spectroscopy
Electron Transport / physiology
Iron / chemistry*,  metabolism
Iron-Sulfur Proteins / physiology
Oxidation-Reduction
Sulfolobus / chemistry*,  metabolism
Chemical
Reg. No./Substance:
0/Iron-Sulfur Proteins; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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