| Evidence for a novel gonadotropin-releasing hormone in hypothalamic and forebrain areas in songbirds. | |
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MedLine Citation:
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PMID: 14673197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One or more of three distinct forms of gonadotropin-releasing hormones (GnRHs), has been found in all vertebrates studied. Birds are known to contain two types of GnRH, chicken GnRH-I and -II (cGnRH-I and -II), but to date nobody has investigated the possibility of the presence of lamprey GnRH-III in birds. Thus, our objective was to investigate the presence and distribution of immunoreactive lamprey (ir-lamprey) GnRH-III in hypothalamic and forebrain areas in house sparrows (Passer domesticus) and Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii). In addition to its distribution in the CNS, we investigated whether or not exogenous lamprey GnRH-III peptide could elicit luteinizing hormone (LH) release in vivo. This study presents two novel findings: 1) The widespread presence in the central nervous system of an immunoreactive third GnRH in birds that is clearly hypophysiotropic and has gonadotropin-releasing capabilities. Intravenous injection of 100 ng lamprey-GnRH-III peptide elicited a rapid rise in circulating luteinizing hormone as compared to controls. This third GnRH, ir-lamprey GnRH-III, likely has multiple functions, as suggested by its widespread distribution. 2) Ir-lamprey GnRH-III is present in abundance in telencephalic areas, including the hippocampal formation and the song control system. In no vertebrate has a GnRH been localized in these 'higher' control regions before. The fact that ir-lamprey-GnRH-III is present in auditory processing areas (higher vocal center, or HVc, area X, caudomedial neostriatum) and song-producing areas (HVc, robust nucleus of the neostriatum, or RA) suggests a direct way in which auditory processing and song production can affect circulating gonadotropins. |
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Authors:
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George E Bentley; Ignacio T Moore; Stacia A Sower; John C Wingfield |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain, behavior and evolution Volume: 63 ISSN: 0006-8977 ISO Abbreviation: Brain Behav. Evol. Publication Date: 2004 |
Date Detail:
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Created Date: 2003-12-15 Completed Date: 2004-03-09 Revised Date: 2008-07-11 |
Medline Journal Info:
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Nlm Unique ID: 0151620 Medline TA: Brain Behav Evol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 34-46 Citation Subset: IM |
Copyright Information:
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Copyright 2004 S. Karger AG, Basel |
Affiliation:
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Department of Biology, University of Washington, Seattle, WA 98195, USA. gb7@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens Female Gonadotropin-Releasing Hormone / classification, metabolism* Hypothalamus / anatomy & histology, metabolism Immunohistochemistry Luteinizing Hormone / secretion* Male Oligopeptides / classification, metabolism* Prosencephalon / anatomy & histology, metabolism* Pyrrolidonecarboxylic Acid / analogs & derivatives Songbirds / anatomy & histology, metabolism* Species Specificity Tissue Distribution Vocalization, Animal / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH65974-01/MH/NIMH NIH HHS; R03 HD39166-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oligopeptides; 0/gonadotropin-releasing hormone-III; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-67-9/Luteinizing Hormone; 98-79-3/Pyrrolidonecarboxylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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