Document Detail

Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage.
MedLine Citation:
PMID:  12640619     Owner:  NLM     Status:  MEDLINE    
Flk1 is one of the specific cell surface receptors for vascular endothelial growth factor and one of the most specific markers highlighting the earliest stage of hematopoietic and vascular lineages. However, recent new evidence suggests that these Flk1(+) mesodermal progenitor cells also contribute to muscle lineages. All evidence is based on the experiments using in vitro differentiation and in vivo transplantation systems. Although this approach revealed a differentiation potential range of Flk1(+) cells that is wider than previously expected, it fails to determine whether Flk1(+) cells contribute to muscle lineage as part of the normal developmental process. To obtain direct evidence for the fate of Flk1(+) cells in development, we used a knock-in mouse line where Cre is expressed in Flk1(+) cells. Studies with these Cre lines provide direct evidence that Flk1(+) cells are progenitors for muscles, in addition to hematopoietic and vascular endothelial cells.
Toshiyuki Motoike; David W Markham; Janet Rossant; Thomas N Sato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  35     ISSN:  1526-954X     ISO Abbreviation:  Genesis     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-11-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8573, USA.
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MeSH Terms
Genes, Reporter
Integrases / genetics,  metabolism
Linkage (Genetics)
Mice, Transgenic
Muscle Development / physiology*
Muscles / embryology*,  metabolism
Receptor, TIE-2 / genetics,  metabolism
Vascular Endothelial Growth Factor Receptor-2 / genetics,  metabolism*
Viral Proteins / genetics,  metabolism
Reg. No./Substance:
0/Viral Proteins; EC, TIE-2; EC Endothelial Growth Factor Receptor-2; EC 2.7.7.-/Cre recombinase; EC 2.7.7.-/Integrases

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