Document Detail


Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage.
MedLine Citation:
PMID:  12640619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Flk1 is one of the specific cell surface receptors for vascular endothelial growth factor and one of the most specific markers highlighting the earliest stage of hematopoietic and vascular lineages. However, recent new evidence suggests that these Flk1(+) mesodermal progenitor cells also contribute to muscle lineages. All evidence is based on the experiments using in vitro differentiation and in vivo transplantation systems. Although this approach revealed a differentiation potential range of Flk1(+) cells that is wider than previously expected, it fails to determine whether Flk1(+) cells contribute to muscle lineage as part of the normal developmental process. To obtain direct evidence for the fate of Flk1(+) cells in development, we used a knock-in mouse line where Cre is expressed in Flk1(+) cells. Studies with these Cre lines provide direct evidence that Flk1(+) cells are progenitors for muscles, in addition to hematopoietic and vascular endothelial cells.
Authors:
Toshiyuki Motoike; David W Markham; Janet Rossant; Thomas N Sato
Related Documents :
24510029 - A novel strategy inducing autophagic cell death in burkitt's lymphoma cells with anti-c...
23512149 - B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cel...
25074359 - Biological effects of sol-gel derived zro2 and sio2/zro2 coatings on stainless steel su...
23002119 - Igm+igd+cd27+ b cells are markedly reduced in irak-4-, myd88-, and tirap- but not unc-9...
23589409 - New strategies in cord blood cells transplantation.
24721609 - Adult, but not neonatal, human lymphoid progenitors respond to tlr9 ligation by produci...
6975679 - Rosette formation with mouse erythrocytes defines a population of human b lymphocytes u...
12237139 - Modulation of sheep lymphocyte responses by fasciola hepatica excretory-secretory produ...
15221869 - Confirmation of mycobacterium tuberculosis infection by flow cytometry after ex vivo in...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  35     ISSN:  1526-954X     ISO Abbreviation:  Genesis     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-11-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8573, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Genes, Reporter
Integrases / genetics,  metabolism
Linkage (Genetics)
Mice
Mice, Transgenic
Muscle Development / physiology*
Muscles / embryology*,  metabolism
Receptor, TIE-2 / genetics,  metabolism
Vascular Endothelial Growth Factor Receptor-2 / genetics,  metabolism*
Viral Proteins / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Viral Proteins; EC 2.7.10.1/Receptor, TIE-2; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2; EC 2.7.7.-/Cre recombinase; EC 2.7.7.-/Integrases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fire exit is a potential four transmembrane protein expressed in developing Drosophila glia.
Next Document:  Versatile inducible activation system of Akt/PKB signaling pathway in mice.