Document Detail

Evidence for noradrenaline and adrenaline as sympathetic transmitters in the chicken.
MedLine Citation:
PMID:  1132     Owner:  NLM     Status:  MEDLINE    
1 The concentrations of noradrenaline and adrenaline in various organs, arterial plasma and venous outflow from isolated hearts of adult chickens have been determined. 2 The relative adrenaline concentrations (percentage of the sum of noradrenaline and adrenaline) in the heart (33%), spleen (16%) and brain (26%) were higher than those found in mammalian organs. Chemical sympathectomy by pretreatment with 6-hydroxydopamine caused a decrease of the noradrenaline and adrenaline concentrations in the heart to 20 and 23% and in the spleen to 16 and 29%, respectively. 3 Stimulation of the right sympathetic nerves, infusion of tyramine or infusion of a modified Tyrode solution containing 108mM K+ and 44 mM Na+ caused an output of both noradrenaline and adrenaline into the perfusate of isolated hearts. The relative adrenaline concentration in the perfusate (20-28%) was not significantly different from the relative adrenaline concentration remaining in these hearts (19-22%). In the individual experiments, the noradrenaline: adrenaline ratios of the stimulation perfusates were positively correlated with the ratios found in the hearts. 4 The effects of noradrenaline and adrenaline on cardiac rate and tension development were studied in spontaneously beating right atria and electrically driven left atria, respectively. In addition, the arterial pressure rise in response to noradrenaline or adrenaline was;measured in chickens. It was found that the cardio-vaseart rate, cardiac tension development and arterial blood pressure, was not significantly different from that of adrenaline. 5 It is concluded that, in the chicken heart and spleen, both noradrenaline and adrenaline act as sympathetic neutrotransmitters.
V P DeSantis; W Långsfeld; R Lindmar; K Loffelholz
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  55     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  IM    
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MeSH Terms
Atrial Function
Blood Pressure
Catecholamines / metabolism
Electric Stimulation
Epinephrine / physiology*
Heart / physiology
Hydroxydopamines / pharmacology
Neurotransmitter Agents / physiology*
Norepinephrine / physiology*
Potassium / pharmacology
Sympathetic Nervous System / physiology*
Tyramine / pharmacology
Reg. No./Substance:
0/Catecholamines; 0/Hydroxydopamines; 0/Neurotransmitter Agents; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-67-2/Tyramine; 7440-09-7/Potassium

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