| Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia. | |
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MedLine Citation:
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PMID: 6294831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake. |
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Authors:
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P L Faris; B R Komisaruk; L R Watkins; D J Mayer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 219 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-02-25 Completed Date: 1983-02-25 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 310-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholecystokinin / pharmacology* Conditioning, Classical Morphine / antagonists & inhibitors* Pain / physiopathology* Receptors, Cell Surface / physiology Receptors, Opioid / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; 0/Receptors, Opioid; 57-27-2/Morphine; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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