Document Detail

Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia.
MedLine Citation:
PMID:  6294831     Owner:  NLM     Status:  MEDLINE    
The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.
P L Faris; B R Komisaruk; L R Watkins; D J Mayer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  219     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  310-2     Citation Subset:  IM    
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MeSH Terms
Cholecystokinin / pharmacology*
Conditioning, Classical
Morphine / antagonists & inhibitors*
Pain / physiopathology*
Receptors, Cell Surface / physiology
Receptors, Opioid / drug effects*
Reg. No./Substance:
0/Receptors, Cell Surface; 0/Receptors, Opioid; 57-27-2/Morphine; 9011-97-6/Cholecystokinin

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