|Evidence for neurogenesis within the white matter beneath the temporal neocortex of the adult rat brain.|
|PMID: 15964698 Owner: NLM Status: MEDLINE|
|Persistent neuron production in the adult CNS (adult neurogenesis) has been implicated in various brain functions such as learning/memory and mood control. Despite the widespread occurrence of neural stem/progenitor cells, active adult neurogenesis has been established only in two restricted regions. We explored in this study a previously overlooked neurogenic region in the adult rat brain and detected the evidence of neuron production within the subcortical white matter. Dividing Pax6- and Olig2-positive neural progenitor cells continually gave rise to doublecortin-positive new neurons in this region. However, the vast majority of newborn neurons were lost within a week of their birth. Accumulated apoptotic cells indicated the ongoing cell death in this area. In addition to providing the evidence of newborn cell migration to the hippocampus, these results suggest that cell genesis, death, and migration persist in a restricted subregion of the adult white matter.|
|N U Takemura|
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|Type: Comparative Study; Journal Article|
|Title: Neuroscience Volume: 134 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2005|
|Created Date: 2005-07-11 Completed Date: 2005-12-02 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States|
|Languages: eng Pagination: 121-32 Citation Subset: IM|
|Department of Neurobiology, the University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Basic Helix-Loop-Helix Transcription Factors / metabolism
Bromodeoxyuridine / administration & dosage, metabolism
Cell Count / methods
Cell Death / physiology
Cell Differentiation / drug effects, physiology*
Cell Proliferation / drug effects
Epidermal Growth Factor / pharmacology
Eye Proteins / metabolism
Fibroblast Growth Factor 2 / pharmacology
Glial Fibrillary Acidic Protein / metabolism
Homeodomain Proteins / metabolism
Immunohistochemistry / methods
In Situ Nick-End Labeling / methods
Intermediate Filament Proteins / metabolism
Microtubule-Associated Proteins / metabolism
Neocortex / cytology*
Nerve Tissue Proteins / metabolism
Neurons / cytology*, drug effects
Neuropeptides / metabolism
Paired Box Transcription Factors / metabolism
Phosphopyruvate Hydratase / metabolism
Rec A Recombinases / metabolism
Repressor Proteins / metabolism
Stem Cells / physiology*
Tubulin / metabolism
|0/Basic Helix-Loop-Helix Transcription Factors; 0/Eye Proteins; 0/Glial Fibrillary Acidic Protein; 0/Homeodomain Proteins; 0/Intermediate Filament Proteins; 0/Microtubule-Associated Proteins; 0/Nerve Tissue Proteins; 0/Neuropeptides; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Repressor Proteins; 0/Tubulin; 0/doublecortin protein; 0/nestin; 103107-01-3/Fibroblast Growth Factor 2; 59-14-3/Bromodeoxyuridine; 62229-50-9/Epidermal Growth Factor; EC 2.7.7.-/Rec A Recombinases; EC 188.8.131.52/Phosphopyruvate Hydratase|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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