Document Detail


Evidence of a net release of tissue-type plasminogen activator across the human cerebral vasculature.
MedLine Citation:
PMID:  15116264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have earlier described models for measuring local net release rates of tissue-type plasminogen activator (t-PA) in vivo across skeletal, coronary, pulmonary, and splanchnic vascular beds. Aim of the present study was to investigate whether there is a net release of t-PA across the human cerebral vascular bed and whether an acute regulated release can be induced by sympathoadrenal activation. Fourteen male subjects undergoing elective coronary artery bypass grafting were investigated prior to surgery and during sternotomy-induced sympathoadrenal activation. Blood samples were obtained simultaneously from the radial artery and the jugular bulb. Blood flow velocity in the middle cerebral artery (V(MCA)) was determined by transcranial Doppler. Cerebral net release of t-PA was calculated as the arterio-venous concentration gradient times V(MCA). Prior to surgery there was a significant cerebral net release of t-PA (131 and 42 ng/min for t-PA antigen and activity, respectively). The release was significantly induced by sternotomy (to 271 and 80 ng/min, respectively). No significant cerebral net release of plasminogen activator inhibitor type 1 (PAI-1) was detected throughout the experiment. The results show that there is a basal net release of t-PA across the human cerebral vascular bed and that sympathoadrenal activation induces a local regulated release of t-PA.
Authors:
Christina Jern; Christian Blomstrand; Anne Westerlind
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  91     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-29     Completed Date:  2004-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1019-25     Citation Subset:  IM    
Affiliation:
Institute of Clinical Neuroscience, Department of Clinical Genetics, Sahlgrenska University Hospital, University of Göteborg, Sweden. christina.jern@neuro.gu.se
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Blood Flow Velocity
Capillary Permeability / physiology
Cerebral Arteries / metabolism*
Cerebrovascular Circulation
Coronary Artery Bypass
Fibrinolysis
Humans
Male
Middle Aged
Plasminogen Activator Inhibitor 1 / blood
Protein Transport
Sympathetic Nervous System / physiology*
Tissue Plasminogen Activator / blood,  metabolism*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Plasminogen Activator Inhibitor 1; EC 3.4.21.68/Tissue Plasminogen Activator

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