Document Detail

Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and grass.
MedLine Citation:
PMID:  20431869     Owner:  NLM     Status:  MEDLINE    
Chloramphenicol (CAP), a broad-spectrum antibiotic, was detected in several herb and grass samples from different geographic origins. Due to its suspected carcinogenicity and linkages with the development of aplastic anemia in humans, CAP is banned for use in food-producing animals in the European Union (EU) and many other countries. However, products of animal origin originating from Asian countries entering the European market are still found noncompliant (containing CAP) on a regular basis, even when there is no history of chloramphenicol use in these countries. A possible explanation for the continued detection of these residues is the natural occurrence of CAP in plant material which is used as animal feed, with the consequent transfer of the substance to the animal tissues. Approximately 110 samples were analyzed using liquid chromatography coupled with mass spectrometric detection. In 26 samples, the presence of CAP was confirmed using the criteria for banned substances defined by the EU. Among other plant materials, samples of the Artemisia family retrieved from Mongolia and from Utah, USA, and a therapeutic herb mixture obtained from local stores in the Netherlands proved to contain CAP at levels ranging from 0.1 to 450 microg/kg. These findings may have a major impact in relation to international trade and safety to the consumer. The results of this study demonstrate that noncompliant findings in animal-derived food products may in part be due to the natural occurrence of chloramphenicol in plant material. This has implications for the application of current EU, USA, and other legislation and the interpretation of analytical results with respect to the consideration of CAP as a xenobiotic veterinary drug residue and the regulatory actions taken upon its detection in food.
Bjorn Berendsen; Linda Stolker; Jacob de Jong; Michel Nielen; Enkhtuya Tserendorj; Ruuragchas Sodnomdarjaa; Andrew Cannavan; Christopher Elliott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-30
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  397     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-09-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1955-63     Citation Subset:  IM    
RIKILT, Wageningen UR, Akkermaalsbos 2, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
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MeSH Terms
Anti-Bacterial Agents / analysis*,  metabolism
Chloramphenicol / analysis*,  metabolism
Chromatography, Liquid
Mass Spectrometry
Plants, Medicinal / chemistry*,  metabolism
Poaceae / chemistry*,  metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; 56-75-7/Chloramphenicol
Comment In:
Anal Bioanal Chem. 2011 Feb;399(6):2223-4; author reply 2225   [PMID:  21243341 ]

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