| Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations. | |
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MedLine Citation:
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PMID: 15090486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous investigations of autoregulatory mechanisms in the control of skin blood flow suffer from the possibility of interfering effects of the autonomic nervous system. To address this question, in 11 subjects cutaneous vascular responses were measured during acute changes in perfusion pressure (using Valsalva maneuver; VM) before and after ganglionic blockade via systemic trimethaphan infusion. Cutaneous vascular conductance at baseline (CVC(base)) and during the last 5 s of the VM (CVC(VM)) were measured from forearm (nonglabrous) and palm (glabrous) skin. During the VM without ganglionic blockade, compared with CVC(base), CVC(VM) decreased significantly at the palm [0.79 +/- 0.17 to 0.55 +/- 0.17 arbitrary units (AU)/mmHg; P = 0.002] but was unchanged at the forearm (0.13 +/- 0.02 to 0.16 +/- 0.02 AU/mmHg; P = 0.50). After ganglionic blockade, VM induced pronounced decreases in perfusion pressure, which resulted in significant increases in CVC(VM) at both forearm (0.19 +/- 0.03 to 0.31 +/- 0.07 AU/mmHg; P = 0.008) and palm (1.84 +/- 0.29 to 2.76 +/- 0.63 AU/mmHg; P = 0.003) sites. These results suggest that, devoid of autonomic control, both glabrous and nonglabrous skin are capable of exhibiting vasomotor autoregulation during pronounced reductions in perfusion pressure. |
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Authors:
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S Durand; R Zhang; J Cui; T E Wilson; C G Crandall |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2004-04-16 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 97 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-12 Completed Date: 2005-01-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 535-9 Citation Subset: IM; S |
Affiliation:
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Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave., Dallas, TX 75231, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology Female Forearm / blood supply*, innervation Ganglia, Sympathetic / drug effects, physiology* Ganglionic Blockers / administration & dosage Heart Rate / physiology Homeostasis / physiology Humans Male Regional Blood Flow / physiology* Skin / blood supply*, innervation Trimethaphan / administration & dosage Valsalva Maneuver / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-10488/HL/NHLBI NIH HHS; HL-61388/HL/NHLBI NIH HHS; HL-67422/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ganglionic Blockers; 7187-66-8/Trimethaphan |
| Investigator | |
Investigator/Affiliation:
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C G Crandall / U TX SW Med Ctr, Dallas |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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